McLeay R A, Stallard J, Watson R D, Littler W A
Arch Mal Coeur Vaiss. 1985 Nov;78 Spec No:41-50.
Nine patients with untreated essential hypertension (random blood pressure 173/109 +/- 14/7 mmHg) were studied before and after 16 weeks' treatment with oral nifedipine 10 mg three times a day. Direct continuous measurement of the systolic and diastolic blood pressures showed that both values were significantly reduced during the 24 hour period. Nifedipine did not change the variability of the blood pressure. There was no significant change in the heart rate after treatment with nifedipine. Long-term nifedipine induced an increase in blood flow in the forearm and decreased the vascular resistances which confirmed the vasodilator effects of the drug. The absolute responses of the blood pressure during postural changes, the hand grip test and cold pressor test were reduced but the treatment did not change the percentage increase in blood pressure during these tests. Long-term nifedipine therapy did not affect the plasma renin activity. The sensitivity and characteristics of the baroreflex response to intravenous phenylephrine were measured. After long-term nifedipine therapy we observed a normalisation of the sino-aortic baroreflex and an increase in its sensitivity. Normalisation of the blood pressure by nifedipine induced a significant reduction in the index of left ventricular mass.
对9例未经治疗的原发性高血压患者（随机血压为173/109±14/7 mmHg）进行研究，在口服硝苯地平10 mg，每日3次，治疗16周前后分别进行观察。直接连续测量收缩压和舒张压显示，24小时期间这两个值均显著降低。硝苯地平未改变血压的变异性。硝苯地平治疗后心率无显著变化。长期服用硝苯地平可使前臂血流量增加，血管阻力降低，证实了该药的血管舒张作用。体位改变、握力试验和冷加压试验期间血压的绝对反应降低，但治疗并未改变这些试验期间血压升高的百分比。长期硝苯地平治疗不影响血浆肾素活性。测量了对静脉注射去氧肾上腺素的压力反射反应的敏感性和特征。长期硝苯地平治疗后，我们观察到窦主动脉压力反射正常化，其敏感性增加。硝苯地平使血压正常化导致左心室质量指数显著降低。
