Zhonghua Nei Ke Za Zhi. 2024 Oct 1;63(10):927-960. doi: 10.3760/cma.j.cn112138-20240229-00135.
Based on the fact that the human gut microbiota dysbiosis can cause various diseases, probiotics have a regulatory effect on human microecological imbalance and can be used to alleviate symptoms of some diseases and/or preventing and treating certain diseases. Probiotics have been widely applied in digestive diseases in both children and adults. Bifidobacterium tetravaccine tablets as a probiotic product contains Bifidobacterium infantis (CGMCC 0460.1), Lactobacillus acidophilus (CGMCC 0460.2), Enterococcus faecalis (CGMCC 0460.3), and Bacillus cereus (CGMCC 0460.4). By combining the unique characteristics of different strains, it exerts therapeutic effects through enhancing intestinal colonization resistance, improving intestinal mucosal barrier function, and modulating immune function, thereby maintaining gut and overall health. Bifidobacterium tetravaccine tablets have been widely used for digestive diseases, with a large number of fundamental and clinical research findings accumulated in the past years, a unified clinical guideline has yet to be achieved. To standardize and guide the rational clinical use of bifidobacterium tetravaccine tablets, this expert consensus have been formulated based on the summary and update of evidence-based medical data, providing a reference for its clinical application.
基于人类肠道微生物群失调可导致多种疾病这一事实，益生菌对人类微生态失衡具有调节作用，可用于缓解某些疾病的症状和/或预防及治疗某些疾病。益生菌已广泛应用于儿童和成人的消化系统疾病。双歧杆菌四联活菌片作为一种益生菌产品，含有婴儿双歧杆菌（CGMCC 0460.1）、嗜酸乳杆菌（CGMCC 0460.2）、粪肠球菌（CGMCC 0460.3）和蜡样芽孢杆菌（CGMCC 0460.4）。通过结合不同菌株的独特特性，它通过增强肠道定植抗力、改善肠道黏膜屏障功能和调节免疫功能发挥治疗作用，从而维持肠道和整体健康。双歧杆菌四联活菌片已广泛用于消化系统疾病，在过去几年积累了大量基础和临床研究结果，但尚未形成统一的临床指南。为规范和指导双歧杆菌四联活菌片的临床合理使用，本专家共识基于循证医学数据的总结和更新而制定，为其临床应用提供参考。
