Moutier R, Toyama K, Lamendin H
C R Acad Sci III. 1985;301(10):483-5.
The cure of osteopetrosis by allogenic bone marrow injection has been obtained in "op" mutant rat kept under cyclosporin A treatment. This immunosuppressive agent able to prevent the rejection of transplanted cells does not impair the propriety of these cells to restore the bone resorption process in this severe osteopetrotic form.
在环孢素A治疗下的“op”突变大鼠中,通过同种异体骨髓注射实现了骨硬化症的治愈。这种能够防止移植细胞排斥的免疫抑制剂不会损害这些细胞在这种严重骨硬化形式中恢复骨吸收过程的能力。