Liu Chenyu, Sha Dongyong, Zhao Lingfei, Zhou Chuanwei, Sun Lili, Liu Changsheng, Yuan Yuan
Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, P.R. China.
Engineering Research Center for Biomedical Materials of the Ministry of Education, East China University of Science and Technology, Shanghai, 200237, P.R. China.
Adv Healthc Mater. 2024 Dec;13(30):e2401687. doi: 10.1002/adhm.202401687. Epub 2024 Oct 7.
Fracture represents one of the most common diagnoses in contemporary medical practice, with the majority of cases traditionally addressed through metallic device fixation. However, this approach is marred by several drawbacks, including prolonged operative durations, considerable expenses, suboptimal applicability to comminuted fractures, increased infection risks, and the inevitable requirement for secondary surgery. The inherent advantages of bone adhesives in these fields have garnered the attention of orthopedic surgeons, who have commenced utilizing biocompatible and biodegradable bone adhesives to bond and stabilize bone fragments. Regrettably, the current bone adhesives generally exhibit insufficient adhesive strength in vivo environments, and it is desirable for them to possess effective osteogenesis to facilitate fracture healing. Consequently, aligning bone adhesives with practical clinical demands remains a significant hurdle, which has catalyzed a surge in research endeavors. Within this review, the conceptual framework, characteristics, and design ideas of bone adhesives based on clinical needs are delineated. Recent advancements in this domain, specifically focusing on the enhancement of two pivotal characteristics-adhesive strength and osteogenic potential are also reviewed. Finally, a prospective analysis of the future advancements in bone adhesives, offering new insights into solutions for diverse clinical problems is presented.
骨折是当代医学实践中最常见的诊断之一，传统上大多数病例通过金属器械固定来处理。然而，这种方法存在几个缺点，包括手术时间延长、费用高昂、对粉碎性骨折的适用性欠佳、感染风险增加以及不可避免地需要二次手术。骨粘合剂在这些领域的固有优势已引起骨科医生的关注，他们已开始使用生物相容性和可生物降解的骨粘合剂来粘结和稳定骨碎片。遗憾的是，目前的骨粘合剂在体内环境中通常表现出不足的粘合强度，并且期望它们具有有效的成骨作用以促进骨折愈合。因此，使骨粘合剂符合实际临床需求仍然是一个重大障碍，这促使了研究工作的激增。在本综述中，阐述了基于临床需求的骨粘合剂的概念框架、特性和设计理念。还综述了该领域的最新进展，特别关注两个关键特性——粘合强度和成骨潜力的增强。最后，对骨粘合剂的未来进展进行了前瞻性分析，为解决各种临床问题提供了新的见解。
