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水通道蛋白5在原发性干燥综合征干眼炎症反应中的作用：潜在治疗靶点探索

The involvement of aquaporin 5 in the inflammatory response of primary Sjogren's syndrome dry eye: potential therapeutic targets exploration.

作者信息

Fu Lijuan, Zhao Zihang, Zhao Shuang, Zhang Meiying, Teng Xiaoming, Wang Liyuan, Yang Tiansong

机构信息

School of Clinical Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.

Ophthalmology Department, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.

出版信息

Front Med (Lausanne). 2024 Sep 23;11:1439888. doi: 10.3389/fmed.2024.1439888. eCollection 2024.

DOI:10.3389/fmed.2024.1439888
PMID:39376655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11456562/
Abstract

Sjogren's syndrome (SS) is a chronic autoimmune disease. Mainly due to the infiltration of lymphoplasmic cells into the exocrine glands, especially the salivary glands and lacrimal glands, resulting in reduced tear and saliva secretion. Reduced tear flow can trigger Sjogren's syndrome dry eye (SSDE). Although the pathophysiology of SSDE xerosis remains incompletely understood, recent advances have identified aquaporin-5 (AQP5) as a critical factor in dysregulation of the exocrine gland and epithelium, influencing the clinical presentation of SSDE through modulation of inflammatory microenvironment and tear secretion processes. This review aims to explore AQP5 regulatory mechanisms in SSDE and analyze its potential as a therapeutic target, providing new directions for SSDE treatment.

摘要

干燥综合征（SS）是一种慢性自身免疫性疾病。主要是由于淋巴细胞浸润外分泌腺，尤其是唾液腺和泪腺，导致泪液和唾液分泌减少。泪液分泌减少可引发干燥综合征干眼（SSDE）。尽管SSDE干燥症的病理生理学仍未完全明确，但最近的研究进展已确定水通道蛋白5（AQP5）是外分泌腺和上皮细胞失调的关键因素，通过调节炎症微环境和泪液分泌过程影响SSDE的临床表现。本综述旨在探讨AQP5在SSDE中的调节机制，并分析其作为治疗靶点的潜力，为SSDE的治疗提供新方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a4/11456562/2c297ab876e6/fmed-11-1439888-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a4/11456562/0a18f5e088f3/fmed-11-1439888-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a4/11456562/e60ead2a7c05/fmed-11-1439888-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a4/11456562/2c297ab876e6/fmed-11-1439888-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a4/11456562/0a18f5e088f3/fmed-11-1439888-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a4/11456562/e60ead2a7c05/fmed-11-1439888-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a4/11456562/2c297ab876e6/fmed-11-1439888-g003.jpg

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本文引用的文献

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Invest Ophthalmol Vis Sci. 2023 Jun 1;64(7):27. doi: 10.1167/iovs.64.7.27.
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Aquaporins in Digestive System.消化系统中的水通道蛋白
Adv Exp Med Biol. 2023;1398:145-154. doi: 10.1007/978-981-19-7415-1_10.
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An Overview of the Dry Eye Disease in Sjögren's Syndrome Using Our Current Molecular Understanding.使用我们目前的分子理解来概述干燥综合征中的干眼疾病。
Int J Mol Sci. 2023 Jan 13;24(2):1580. doi: 10.3390/ijms24021580.
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Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies.人及大鼠泪腺组织化学比较：对生物工程研究的启示。
Transl Vis Sci Technol. 2022 Nov 1;11(11):10. doi: 10.1167/tvst.11.11.10.
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Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy.水通道蛋白基因治疗纠正 LAMP3 相关的唾液腺功能低下。
Sci Rep. 2022 Nov 3;12(1):18570. doi: 10.1038/s41598-022-21374-2.
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Candidate autoantibodies for primary Sjögren's syndrome: where are they now?原发性干燥综合征的候选自身抗体：它们现在在哪里？
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Dry eye in Sjögren's syndrome - characteristics and therapy.干燥性角结膜炎综合征中的干眼症——特征和治疗。
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