Saldarriaga Osuna Luis Fernando, Muñoz Rossi Felipe A, Diaz Adrián, Núñez De Larosa Melisa, Mosquera López Edgar Dario, Mejia Fajardo Maria Clara, Rodriguez Cortes Alba Del Pilar, Coronel Arauz Jonathan H, Reche Martinez Antonio J, Rico Rios Natividad
General Medicine, Universidad Nacional de Colombia, Bogotá, COL.
Internal Medicine, Universidad Nacional de Colombia, Bogotá, COL.
Cureus. 2024 Sep 3;16(9):e68520. doi: 10.7759/cureus.68520. eCollection 2024 Sep.
Venous thromboembolic disease (VTE) is an episodic condition of multifactorial origin, commonly manifesting as deep vein thrombosis (DVT) and pulmonary embolism (PE). VTE is a major cause of morbidity and mortality. As an acute condition, it has the potential for recurrence and is associated with major consequences; this disease poses significant challenges to the healthcare system. VTE is a widespread concern in developed and developing countries; therefore, it is not limited to specific regions or populations.
To evaluate the risk factors associated with unprovoked PE in patients in a hospital center in Sincelejo, Colombia.
This is an observational, analytical cross-sectional study utilizing retrospective data. From 2010 to 2023, we reviewed 126 medical records of patients who experienced their first unprovoked VTE events and met the inclusion criteria. We performed data analysis using R software version 3.5.1.
Of the patients, 36.5% (n = 46) were women; 63.5% (n = 80) were men, with a mean age of 62.22 years (SD = 10.62). About 53% of women presented with PE, compared to 47% of men. The coagulation factor VIII acted as a PE risk factor (p = 0.098). The best model to predict PE development obtained an Akaike information criterion (AIC) of 176.67, indicating that the A1 positive phenotype is the risk factor with the highest prediction for PE occurrence.
High levels of coagulation factor VIII and an A1-positive phenotype are risk factors that may increase PE development. These findings suggest the need for preventive strategies in this risk setting to reduce the incidence and recurrence of PE.
静脉血栓栓塞性疾病（VTE）是一种多因素起源的发作性疾病，通常表现为深静脉血栓形成（DVT）和肺栓塞（PE）。VTE是发病和死亡的主要原因。作为一种急性疾病，它有复发的可能性，并伴有严重后果；这种疾病给医疗系统带来了重大挑战。VTE在发达国家和发展中国家都是一个广泛关注的问题；因此，它不限于特定地区或人群。
评估哥伦比亚辛塞莱霍一家医院中心患者中与特发性PE相关的危险因素。
这是一项利用回顾性数据的观察性分析横断面研究。从2010年到2023年，我们回顾了126例首次发生特发性VTE事件并符合纳入标准的患者的病历。我们使用R软件3.5.1版进行数据分析。
在这些患者中，36.5%（n = 46）为女性；63.5%（n = 80）为男性，平均年龄为62.22岁（标准差 = 10.62）。约53%的女性表现为PE，而男性为47%。凝血因子VIII是PE的一个危险因素（p = 0.098）。预测PE发生的最佳模型的赤池信息准则（AIC）为176.67，表明A1阳性表型是对PE发生预测性最高的危险因素。
凝血因子VIII水平升高和A1阳性表型是可能增加PE发生的危险因素。这些发现表明需要在这种风险情况下采取预防策略，以降低PE的发病率和复发率。
