Haroutunian Sara G, Hoseen Rana, Farmand Donya, Camilon Marinelle, Hashemi Sanaz
Medicine, Ross University School of Medicine, Bridgetown, BRB.
Internal Medicine, California Hospital Medical Center, Los Angeles, USA.
Cureus. 2024 Sep 7;16(9):e68879. doi: 10.7759/cureus.68879. eCollection 2024 Sep.
Morvan syndrome, also known as Morvan's fibrillary chorea, is a rare paraneoplastic neurological syndrome presenting with central nervous system (CNS) symptoms, peripheral nerve hyperexcitability, and autonomic nervous system (ANS) manifestations. The etiology and severity of the disease are not well understood. An adult female presented with a sudden onset of chest pain, unilateral extremity weakness, blepharospasms, and muscle spasms, with positive voltage-gated potassium channel (VGKC) antibody and positive neuronal antibody (amphiphysin) in serum. Morvan syndrome can be diagnosed in patients with myokymia, positive VGKC antibody, and neuropsychiatric symptoms with a high clinical index of suspicion. This atypical presentation of Morvan syndrome in a female identifies a novel association of amphiphysin positivity in this rare disease.
莫旺综合征，也称为莫旺纤维性舞蹈病，是一种罕见的副肿瘤性神经综合征，表现为中枢神经系统（CNS）症状、周围神经兴奋性增高和自主神经系统（ANS）表现。该疾病的病因和严重程度尚不清楚。一名成年女性突然出现胸痛、单侧肢体无力、眼睑痉挛和肌肉痉挛，血清中电压门控钾通道（VGKC）抗体阳性和神经元抗体（抗 amphiphysin 抗体）阳性。对于有肌束震颤、VGKC 抗体阳性且有神经精神症状且临床怀疑指数较高的患者可诊断为莫旺综合征。莫旺综合征在女性中的这种非典型表现确定了这种罕见疾病中抗 amphiphysin 抗体阳性的一种新关联。
