锂化烯丙基砜对非外消旋亚磺酰亚胺的非对映选择性加成：多种杂环的不对称合成
Diastereoselective Addition of Lithiated Allenyl Sulfones to Nonracemic Sulfinimines: Asymmetric Synthesis of Diverse Heterocycles.
作者信息
Gadhave Mahesh S, Prasad Kavirayani R
机构信息
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India.
出版信息
J Org Chem. 2024 Oct 18;89(20):15364-15373. doi: 10.1021/acs.joc.4c01982. Epub 2024 Oct 8.
PMID:39377104
Abstract
The addition of lithiated allenyl sulfones to nonracemic sulfinimines furnished sulfinamides possessing the allenyl sulfonyl moiety with excellent diastereoselectivity. The formed products are transformed into different heterocycles, including the synthesis of pyrroline, pyran, and functionalized benzopyran.
摘要
将锂化的烯丙基砜添加到非外消旋亚磺酰亚胺中，可提供具有烯丙基磺酰基部分的亚磺酰胺，具有出色的非对映选择性。所形成的产物可转化为不同的杂环，包括吡咯啉、吡喃和功能化苯并吡喃的合成。
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