Curry T E, Lawrence I E, Burden H W
Exp Clin Endocrinol. 1985 Dec;86(3):284-90. doi: 10.1055/s-0029-1210498.
The role of adrenergic nerves in estrous cyclicity and follicular growth was studied in sympathectomized hamster ovaries. Specific ovarian sympathectomy was accomplished by injection of 6-hydroxydopamine (6-OHDA) into the ovarian bursal sac. Ovarian sympathectomy abolished all fluorescent adrenergic nerves 4, 8 or 12 days after treatment. Bilateral ovarian sympathectomy on metestrus altered the first estrous cycle in 53% of the animals and 20% had an altered second cycle. All sham injected animals had normal cycles. Four days after sympathectomy, there was a decrease in healthy follicles 80-240 microns and 250-340 microns in diameter and increased atresia of follicles 80-240 microns and 350-440 microns in diameter compared to solvent treated ovaries. Bilateral 6-OHDA treatment did not affect ovarian weight, number of corpora lutea or the total number of follicles per ovary. These observations suggest that ovarian adrenergic nerves modulate healthy follicular development in the golden hamster.
在去交感神经的仓鼠卵巢中研究了肾上腺素能神经在发情周期和卵泡生长中的作用。通过向卵巢囊内注射6-羟基多巴胺（6-OHDA）实现特异性卵巢去交感神经切除术。治疗后4、8或12天，卵巢去交感神经切除术消除了所有荧光肾上腺素能神经。在动情后期进行双侧卵巢去交感神经切除术，53%的动物的第一个发情周期发生改变，20%的动物的第二个发情周期发生改变。所有假注射动物的周期均正常。与溶剂处理的卵巢相比，去交感神经切除术后4天，直径80 - 240微米和250 - 340微米的健康卵泡数量减少，直径80 - 240微米和350 - 440微米的卵泡闭锁增加。双侧6-OHDA处理不影响卵巢重量、黄体数量或每个卵巢的卵泡总数。这些观察结果表明，卵巢肾上腺素能神经调节金黄仓鼠的健康卵泡发育。
