大环内酯类耐药谱在复杂肺部疾病中的变化。
Variability of macrolide-resistant profile in complex pulmonary disease.
机构信息
Department of Respiratory Medicine, National Hospital Organization, Osaka Toneyama Medical Center, Toyonaka, Osaka, Japan.
Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
出版信息
Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0121324. doi: 10.1128/aac.01213-24. Epub 2024 Oct 8.
This single-center retrospective study aimed to analyze the variability of macrolide resistance (MR) in 68 patients with complex pulmonary disease. Among 25 patients treated without macrolides, 13 (52%) reverted to macrolide-susceptible (MS) profiles. Only one (2%) of 43 patients who continued macrolide treatment showed this change. We compared 30 MR isolates with recent specimens. Among them, seven shifted to MS (five attributed to clonally related strains; two resulting from reinfection or polyclonal infection).
本单中心回顾性研究旨在分析 68 例患有复杂肺部疾病患者的大环内酯类药物耐药性 (MR) 的变异性。在 25 例未使用大环内酯类药物治疗的患者中，13 例（52%）恢复为大环内酯类敏感（MS）表型。在继续大环内酯类药物治疗的 43 例患者中，只有 1 例（2%）出现这种变化。我们比较了 30 株 MR 分离株与近期标本。其中，7 株转为 MS（5 株归因于克隆相关菌株；2 株是再感染或多克隆感染的结果）。
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