Soltanieh Sina Kalantari, Khastar Sahar, Kaur Irwanjot, Kumar Abhishek, Bansal Jaya, Fateh Ata, Nathiya Deepak, Husseen Beneen, Rajabivahid Mansour, Dehghani-Ghorbi Mahmoud, Akhavan-Sigari Reza
MVZ Labor Synlab Berlin, Berlin, Germany.
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cell Biochem Biophys. 2025 Mar;83(1):279-294. doi: 10.1007/s12013-024-01555-8. Epub 2024 Oct 8.
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a range of conditions that start with the accumulation of fat in the liver (hepatic steatosis) and can progress to more severe stages like steatohepatitis (NASH) and fibrosis without drinking alcohol. Environmental and genetic variables both contribute to MAFLD's development, with various biological processes and mediators involved at every phase. Long non-coding RNAs (lncRNAs) are a class of RNA molecules that are not translated into protein and are over 200 nucleotides long. They can impact genes that encode protein by controlling transcriptional and post-transcriptional procedures. Dysregulation of lncRNA has been connected to several liver diseases, including MAFLD. Recent research has linked lncRNAs to MAFLD pathology in both patients and animal models. However, the roles of most lncRNAs in MAFLD pathology are still not well recognized. This review provides a comprehensive catalog of recently reported lncRNAs in the pathogenesis of MAFLD and summarizes the current knowledge of lncRNAs usage as therapeutic strategies in MAFLD, the most common liver disease. Collectively, lncRNA's targeting could potentially offer a therapeutic approach by modulating MAFLD.
代谢功能障碍相关脂肪性肝病（MAFLD）是一系列始于肝脏脂肪堆积（肝脂肪变性）的病症，在无饮酒情况下可进展至更严重阶段，如脂肪性肝炎（NASH）和肝纤维化。环境和遗传变量均对MAFLD的发展有影响，各个阶段涉及多种生物学过程和介质。长链非编码RNA（lncRNA）是一类不翻译成蛋白质且长度超过200个核苷酸的RNA分子。它们可通过控制转录和转录后过程影响编码蛋白质的基因。lncRNA的失调与包括MAFLD在内的多种肝脏疾病有关。最近的研究已将lncRNA与患者和动物模型中的MAFLD病理联系起来。然而，大多数lncRNA在MAFLD病理中的作用仍未得到充分认识。本综述提供了最近报道的MAFLD发病机制中lncRNA的综合目录，并总结了目前关于lncRNA作为最常见肝脏疾病MAFLD治疗策略的知识。总体而言，靶向lncRNA可能通过调节MAFLD提供一种治疗方法。
