Obstetrics and Gynecology, Sanliurfa Education and Research Hospital, Sanliurfa, Turkey.
Department of Internal Medicine, Cigdem Cindoglu Assoc/Prof, Harran University Medical Faculty, Sanliurfa, Turkey.
J Obstet Gynaecol. 2024 Dec;44(1):2408680. doi: 10.1080/01443615.2024.2408680. Epub 2024 Oct 8.
Preeclampsia is still a disease whose cause and treatment have not been fully characterised. Early-onset preeclampsia occurs before the 34th week of pregnancy, and late-onset preeclampsia occurs at 34 weeks or older. In our study, we investigated whether the prognostic nutritional index (PNI) and pan immune inflammation value (PIV), which are used in the prognosis and prediction of diseases in new studies in the literature, are useful for predicting early-onset preeclampsia.
The first group consisted of healthy pregnant women who had a single foetus without any additional disease between 24 and 34 gestational weeks, and the second group consisted of pregnant women who were diagnosed with early-onset preeclampsia and did not have any additional disease or foetal anomalies during the same gestational week. Neutrophil, lymphocyte, monocyte, thrombocyte, ALB, pan immune inflammation value (PIV) and prognostic nutritional index (PNI) scores were recorded.
In our case control study, 70 patients with early-onset preeclampsia and 140 pregnant women composed the normotensive (control) group. There was a significant difference between the groups according to PIV (p = 0.04). The prognostic nutritional index (PNI) was significantly lower in the early-onset preeclampsia group than in the normotensive group (p < 0,001). A PNI lower than 36, 30 could only predict early-onset preeclampsia with a low sensitivity of 31.1% and specificity of 45%; the area under the curve was 0,24 (95% confidence interval 0.18-0.31), < 0,001.
Patients with PNI scores lower than 36,30 may have early-onset preeclampsia.
子痫前期仍然是一种病因和治疗方法尚未完全明确的疾病。早发型子痫前期发生在怀孕 34 周之前，晚发型子痫前期发生在 34 周或以上。在我们的研究中，我们研究了预后营养指数（PNI）和全免疫炎症值（PIV），这两个指标在文献中的新研究中用于疾病的预后和预测，是否可用于预测早发型子痫前期。
第一组由 24 至 34 孕周单胎妊娠且无其他疾病的健康孕妇组成，第二组由同一孕周诊断为早发型子痫前期且无其他疾病或胎儿异常的孕妇组成。记录中性粒细胞、淋巴细胞、单核细胞、血小板、白蛋白、全免疫炎症值（PIV）和预后营养指数（PNI）评分。
在我们的病例对照研究中，70 例早发型子痫前期患者和 140 例正常血压孕妇组成了正常血压（对照组）。根据 PIV，两组之间存在显著差异（p=0.04）。早发型子痫前期组的预后营养指数（PNI）明显低于正常血压组（p<0.001）。PNI 低于 36、30 只能预测早发型子痫前期，敏感性为 31.1%，特异性为 45%；曲线下面积为 0.24（95%置信区间 0.18-0.31），<0.001。
PNI 评分低于 36、30 的患者可能患有早发型子痫前期。
