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迈向用于治疗听力损失的干细胞疗法:澳大利亚听力学家及其患者的认知与观点。

Towards stem cell therapies for hearing loss: awareness and perspectives of Australian audiologists and their patients.

作者信息

Iem Dysiphan, Carney Georgia, Munsie Megan, Nayagam Bryony A

机构信息

Department of Audiology & Speech Pathology, University of Melbourne, 3010, Australia.

Murdoch Children's Research Institute, Melbourne, 3052, Australia.

出版信息

Regen Med. 2024 Sep-Oct;19(9-10):483-496. doi: 10.1080/17460751.2024.2402650. Epub 2024 Oct 8.

Abstract

Over the last two decades, numerous experimental studies have examined the feasibility of delivering stem cells into the cochlea to restore hearing. While these studies have spawned new cell therapy companies, there is little information on what patients understand or expect from these emerging therapies. This study sought to understand the awareness and perspectives of Australian audiologists and their adult patients toward stem cell therapies for treating hearing loss. An anonymous survey indicated 91% of patients and 39% of audiologists were unaware of these therapies being developed. Thirty percent of audiologists reported being asked about stem cell therapies for hearing loss, but 70% were not confident answering patient queries about this and were unsure where to gather information. Primary concerns reported by patients were cost (45%) and safety of treatment (42%). Interestingly, 58% of patients were unsure of how this therapy would improve their hearing, yet 25% of these patients expected that their hearing would return to normal. There was strong support for development of educational materials for both patient and clinician. The increasingly important role of audiologists in providing patient counselling was reflected in overwhelming support (from both patient and clinician) for audiologists providing such information.

摘要

在过去二十年中,众多实验研究探讨了将干细胞输送到耳蜗以恢复听力的可行性。虽然这些研究催生了新的细胞治疗公司,但关于患者对这些新兴疗法的理解或期望的信息却很少。本研究旨在了解澳大利亚听力学家及其成年患者对治疗听力损失的干细胞疗法的认知和看法。一项匿名调查显示,91%的患者和39%的听力学家不知道正在研发这些疗法。30%的听力学家报告称曾被问及治疗听力损失的干细胞疗法,但70%的人对回答患者关于此疗法的问题没有信心,并且不确定从何处获取信息。患者报告的主要担忧是费用(45%)和治疗安全性(42%)。有趣的是,58%的患者不确定这种疗法将如何改善他们的听力,但其中25%的患者期望他们的听力能恢复正常。对于为患者和临床医生开发教育材料有强烈的支持。听力学家在提供患者咨询方面日益重要的作用体现在(患者和临床医生)对听力学家提供此类信息的压倒性支持上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc0/11487944/c20d0e9fa70d/IRME_A_2402650_F0001_B.jpg

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