Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Brain Behav. 2024 Oct;14(10):e70090. doi: 10.1002/brb3.70090.
The association among coronary heart disease, ischemic stroke, and hydrocephalus remains ambiguous.
There is a need for a Mendelian randomization study to evaluate the underlying causality between coronary heart disease, ischemic stroke, and hydrocephalus.
The data source utilized genome-wide association studies, employing a threshold of p < 5 × 10 to identify single nucleotide polymorphisms strongly linked to ischemic stroke and coronary heart disease as instrumental variables (IVs). Five methods-inverse variance weighted (IVW), Mendelian randomization (MR) Egger, Weighted Median, Weighted mode, and Simple mode-utilized the selected IVs to estimate the causality between ischemic stroke, coronary heart disease, and hydrocephalus.
The IVW demonstrated that ischemic stroke and coronary heart disease serve as risk factors for hydrocephalus (odds ratio [OR] = 1.650, 95% CI: 1.066-2.554, p = 0.025; OR = 1.307, 95% CI: 1.023-1.668, p = 0.032). Both the MR-Egger intercept test and Cochran's Q test affirmed the relative reliability of the IVW analysis results. However, no evidence of a reverse causation was observed between hydrocephalus and coronary heart disease or ischemic stroke.
Coronary heart disease and Ischemic stroke may increase the risk of hydrocephalus.
冠心病、缺血性卒中和脑积水之间的关联仍不清楚。
需要进行孟德尔随机化研究，以评估冠心病、缺血性卒中和脑积水之间的潜在因果关系。
利用全基因组关联研究的数据，采用 p < 5 × 10 的阈值，确定与缺血性卒中和冠心病密切相关的单核苷酸多态性作为工具变量（IVs）。使用所选 IVs 采用逆方差加权（IVW）、孟德尔随机化（MR）Egger、加权中位数、加权模式和简单模式五种方法，估计缺血性卒中和冠心病与脑积水之间的因果关系。
IVW 表明，缺血性卒中和冠心病是脑积水的危险因素（比值比 [OR] = 1.650，95%置信区间：1.066-2.554，p = 0.025；OR = 1.307，95%置信区间：1.023-1.668，p = 0.032）。MR-Egger 截距检验和 Cochran's Q 检验均证实了 IVW 分析结果的相对可靠性。然而，没有证据表明脑积水与冠心病或缺血性卒中之间存在反向因果关系。
冠心病和缺血性卒中可能会增加脑积水的风险。
