Podiatric Medicine and Surgery, Department of Orthopedics, University of Louisville, Louisville, KY.
Wounds. 2024 Sep;36(9):323-326. doi: 10.25270/wnds/24058.
Pyoderma gangrenosum (PG) is a rare skin condition that is challenging for both patients and physicians alike. It is extremely painful and can become debilitating for many patients. PG has a mortality rate of 16% at 8 years, and patients with PG have a threefold risk of death compared to the general population. Currently, the management of PG is not standardized and is somewhat experimental as these wounds are prone to pathergy.
A single patient diagnosed with PG of both lower extremities was successfully treated with a protocol that included serial wound debridement with a sterile scrub brush and hydrodebridement followed by application of a synthetic hybrid-scale fiber matrix (SHSFM) dressing. The patient's wounds successfully healed and the resolution was maintained at 2 years, at which time the patient was discharged from the clinic.
To the authors' knowledge, this is the first study reporting the use of SHSFM as a primary treatment option for PG.
坏疽性脓皮病（PG）是一种罕见的皮肤疾病，对患者和医生来说都是极具挑战性的。它非常疼痛，会使许多患者丧失行动能力。PG 在 8 年内的死亡率为 16%，与普通人群相比，患有 PG 的患者死亡风险增加了两倍。目前，PG 的治疗尚未标准化，有些属于试验性治疗，因为这些伤口容易出现假性化脓。
一位下肢均患有 PG 的单一患者，成功接受了一项方案的治疗，该方案包括使用无菌擦洗刷进行多次伤口清创和水疗清创，然后使用合成混合鳞片纤维基质（SHSFM）敷料。患者的伤口成功愈合，2 年后仍保持愈合状态，此时患者已从诊所出院。
据作者所知，这是首例报道使用 SHSFM 作为 PG 的主要治疗选择的研究。
