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岩斜区脑膜瘤的自发消退:病例说明

Spontaneous regression of a petroclival meningioma: illustrative case.

作者信息

Noda Ryuichi, Kawashima Mariko, Akabane Atsuya, Inoue Tomohiro

机构信息

Department of Gamma Knife Center, NTT Medical Center Tokyo, Shinagawa-ku, Tokyo, Japan.

Department of Neurosurgery, NTT Medical Center Tokyo, Shinagawa-ku, Tokyo, Japan.

出版信息

J Neurosurg Case Lessons. 2024 Oct 7;8(15). doi: 10.3171/CASE24416.

DOI:10.3171/CASE24416
PMID:39378522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11465344/
Abstract

BACKGROUND

Spontaneous regression is relatively rare in meningiomas. Since meningiomas are known to have a relationship with sex-related hormones, spontaneous regression cases related to sex hormones have been reported.

OBSERVATIONS

A 66-year-old man with a petroclival meningioma was radiologically followed up for 13 years. The tumor initially measured 2.535 cm3 and 2.521 cm3 on gadolinium-enhanced magnetic resonance imaging (MRI) and fast imaging employing steady-state acquisition MRI, respectively. However, the measurements decreased in the follow-up period to 0.977 cm3 and 0.98 cm3, respectively, demonstrating spontaneous regression of an asymptomatic meningioma located in a petroclival area. Continuous meticulous long-term follow-up revealed this phenomenon.

LESSONS

It is important to retain the option of conservative treatment for patients ineligible for surgery for reasons such as advanced age and coexisting diseases. https://thejns.org/doi/10.3171/CASE24416.

摘要

背景

脑膜瘤的自发消退相对少见。由于已知脑膜瘤与性激素有关,因此已有与性激素相关的自发消退病例报道。

观察结果

一名患有岩斜脑膜瘤的66岁男性接受了13年的影像学随访。在钆增强磁共振成像(MRI)和稳态采集快速成像MRI上,肿瘤最初体积分别为2.535 cm³和2.521 cm³。然而,在随访期间,测量值分别降至0.977 cm³和0.98 cm³,表明位于岩斜区的无症状脑膜瘤出现了自发消退。持续细致的长期随访发现了这一现象。

经验教训

对于因年龄较大和并存疾病等原因而不适合手术的患者,保留保守治疗的选择很重要。https://thejns.org/doi/10.3171/CASE24416 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a8/11465344/991d99d056f7/CASE24416_figure_3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a8/11465344/4d9419abec64/CASE24416_figure_1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a8/11465344/b2ae35c33025/CASE24416_figure_2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a8/11465344/991d99d056f7/CASE24416_figure_3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a8/11465344/4d9419abec64/CASE24416_figure_1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a8/11465344/b2ae35c33025/CASE24416_figure_2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a8/11465344/991d99d056f7/CASE24416_figure_3.jpg

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本文引用的文献

1
Regression of Multiple Intracranial Meningiomas With Cessation of Progesterone Agonist Therapy: A Case Report.停用孕激素激动剂治疗后多发性颅内脑膜瘤消退:一例报告
Cureus. 2024 Jan 18;16(1):e52479. doi: 10.7759/cureus.52479. eCollection 2024 Jan.
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Meningioma With Partial and Spontaneous Regression of Peritumoral Edema on Long-Term Follow Up.长期随访中肿瘤周围水肿部分自发消退的脑膜瘤
Brain Tumor Res Treat. 2022 Oct;10(4):275-278. doi: 10.14791/btrt.2022.0040.
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Spontaneous regression of a posterior fossa meningioma: A case report.
后颅窝脑膜瘤的自发消退:一例报告。
Surg Neurol Int. 2022 Aug 5;13:334. doi: 10.25259/SNI_429_2022. eCollection 2022.
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Advances in Molecular Biological and Translational Studies in World Health Organization Grades 2 and 3 Meningiomas: A Literature Review.世界卫生组织 2 级和 3 级脑膜瘤分子生物学和转化研究进展:文献综述。
Neurol Med Chir (Tokyo). 2022 Aug 15;62(8):347-360. doi: 10.2176/jns-nmc.2022-0114. Epub 2022 Jul 22.
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Natural history of meningiomas: a serial volumetric analysis of 240 tumors.脑膜瘤的自然史:240 例肿瘤的连续体积分析。
J Neurosurg. 2022 Apr 29;137(6):1639-1649. doi: 10.3171/2022.3.JNS212626. Print 2022 Dec 1.
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Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report.慢性激素治疗中断后多发性脑膜瘤的消退:一例报告
J Neurol Surg Rep. 2021 Dec 1;82(4):e38-e42. doi: 10.1055/s-0041-1735553. eCollection 2021 Oct.
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The Impact of 5-Year Tumor Doubling Time to Predict the Subsequent Long-Term Natural History of Asymptomatic Meningiomas.5 年肿瘤倍增时间对预测无症状脑膜瘤后续长期自然史的影响。
World Neurosurg. 2021 Jul;151:e943-e949. doi: 10.1016/j.wneu.2021.05.023. Epub 2021 May 18.
8
The spatial phenotype of genotypically distinct meningiomas demonstrate potential implications of the embryology of the meninges.不同基因型脑膜瘤的空间表型显示了脑膜胚胎学的潜在意义。
Oncogene. 2021 Feb;40(5):875-884. doi: 10.1038/s41388-020-01568-6. Epub 2020 Dec 1.
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A prospective study of the natural history of incidental meningioma-Hold your horses!一项关于偶然发现的脑膜瘤自然病史的前瞻性研究——别急!
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Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients.醋酸甲羟孕酮停药后脑膜瘤自发消退:三例系列报告。
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