Huang Kai, Zhang Zeling, Hu Meihong, Zhao Jiawen, Li Zhenhua, Hu Chengyang, Bai Shun, Wu Dequan, Wu Yile, Hu Xiaoqian, Wang Xueping, Yan Xiang, Li Ruojie, Xu Bo, Zhang Xiu-Jun
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China; The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China.
Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
Int J Hyg Environ Health. 2025 Jan;263:114474. doi: 10.1016/j.ijheh.2024.114474. Epub 2024 Oct 7.
The associations of air pollutants exposure with assisted reproductive technology (ART) pregnancy outcomes are mixed, and the effects of specific components of fine particulate matter (PM) and ozone (O) are not well understood. We conducted a retrospective longitudinal study to explore the association of PM constituents and O exposure with three ART outcomes among women undergoing ART treatment. The exposure window was segmented into five periods corresponding to the cycle of ovarian stimulation and oocyte retrieval procedure. Generalized linear mixed model (GLMM) was applied to explore the relationships between PM constituents, O Normalized Vegetation Index (NDVI) exposure and three ART outcomes. The combined effect of PM constituents was evaluated by the quantile g (qg)-computation. We also explored the modifying effect of different covariate. Elevated exposure level of PM (OR = 0.915, 95% CI: 0.859, 0.974) and its constituents (BC: 0.905, 95% CI: 0.840, 0.975; OM: 0.910, 95% CI: 0.848, 0.976; NO: 0.909, 95% CI: 0.850, 0.972, SO: 0.905, 95% CI: 0.846, 0.968, and NH: 0.902, 95% CI: 0.842, 0.966) exposure throughout the year before oocyte retrieval (period 1) was correlated with a reduced odds ratio (OR) of live birth with statistical significance. Similarly, for each interquartile range (IQR) increase in O exposure during periods 2 (85 days prior to oocyte retrieval), 3 (30 days prior to oocyte retrieval), 4 (oocyte retrieval to embryo transfer) and 5 (embryo transfer to hCG test) was significantly related to a decreased OR of live birth. Especially, participants who underwent fresh embryo transfer cycles and received two cleavage-stage embryo transfer, and were younger than 30 years old, showed a higher susceptibility to particulate matter. Findings from this study suggest that PM constituents and O exposure may have adverse effects on the ART outcomes, highlighting the importance of identifying critical exposure periods for various air pollutants and the need for meticulous management of particulate matter.
空气污染物暴露与辅助生殖技术（ART）妊娠结局之间的关联尚无定论，细颗粒物（PM）和臭氧（O）的特定成分的影响也未得到充分了解。我们进行了一项回顾性纵向研究，以探讨接受ART治疗的女性中PM成分和O暴露与三种ART结局之间的关联。暴露窗口被划分为与卵巢刺激周期和卵母细胞取卵程序相对应的五个时期。应用广义线性混合模型（GLMM）来探讨PM成分、O归一化植被指数（NDVI）暴露与三种ART结局之间的关系。通过分位数g（qg）计算评估PM成分的综合效应。我们还探讨了不同协变量的修正效应。在卵母细胞取卵前一年（第1期），PM（OR = 0.915，95% CI：0.859，0.974）及其成分（BC：0.905，95% CI：0.840，0.975；OM：0.910，95% CI：0.848，0.976；NO：0.909，95% CI：从0.850到0.972，SO：0.905，95% CI：0.846，0.968，以及NH：0.902，95% CI：0.842，0.966）的暴露水平升高与活产几率降低相关，具有统计学意义。同样，在第2期（卵母细胞取卵前85天）、第3期（卵母细胞取卵前30天）、第4期（卵母细胞取卵至胚胎移植）和第5期（胚胎移植至hCG检测）期间，O暴露每增加一个四分位数间距（IQR），均与活产几率显著降低相关。特别是，接受新鲜胚胎移植周期且移植两个卵裂期胚胎、年龄小于30岁的参与者，对颗粒物更为敏感。本研究结果表明，PM成分和O暴露可能对ART结局产生不利影响，凸显了确定各种空气污染物关键暴露期的重要性以及对颗粒物进行精细管理的必要性。
