Nematbakhsh Roxana, Rouhani Parisa, Saneei Parvane
Students' Scientific Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Obes Rev. 2025 Feb;26(2):e13850. doi: 10.1111/obr.13850. Epub 2024 Oct 8.
Numerous studies have examined the relationship of calcium intake and metabolic syndrome (MetS) in adults in previous decades; but the results were inconsistent across different societies. This systematic review and dose-response meta-analysis assessed the relation between calcium consumption and MetS in adults. We did a systematic search of all articles published up to July 2023 in Scopus, PubMed/Medline, ISI Web of Science electronic databases, and Google Scholar. Observational studies investigated the association between dietary calcium (Ca) intake and MetS in adults were eligible to be included. For computing the estimates, a random effects model was applied. Combining 24 effect size from 17 investigations (15 cross-sectional and two cohort studies) with 74,720 participants and 18,200 cases showed that highest versus lowest level of dietary Ca intake was related to 23% significant decreased odds of MetS (OR = 0.77; 95% CI: 0.66, 0.89). Linear dose-response analysis of estimates from 12 investigations showed that each 100 mg/day increment in dietary Ca intake was associated with 3% marginally significant decreased odds in MetS (OR = 0.97; 95%CI: 0.93, 1.01). In nonlinear dose-response analysis of 12 studies with 67,896 participants, a significant association between dietary calcium intake and MetS was found (P <0.001); such that 500 mg/day dietary calcium intake was related to maximum decrease in odds of MetS. According to this meta-analysis, the likelihood of MetS was significantly lower in adults with higher level of dietary calcium intake. Further large-scale prospective cohort investigations are needed to obtain stronger and more accurate results.
在过去几十年中，众多研究探讨了成年人钙摄入量与代谢综合征（MetS）之间的关系；但不同社会的研究结果并不一致。本系统评价和剂量反应荟萃分析评估了成年人钙摄入量与代谢综合征之间的关系。我们对截至2023年7月在Scopus、PubMed/Medline、ISI Web of Science电子数据库和谷歌学术上发表的所有文章进行了系统检索。纳入了观察性研究，这些研究调查了成年人膳食钙（Ca）摄入量与代谢综合征之间的关联。为了计算估计值，应用了随机效应模型。综合17项研究（15项横断面研究和2项队列研究）中的24个效应量，涉及74720名参与者和18200例病例，结果显示，膳食钙摄入量最高与最低水平相比，代谢综合征的显著降低几率为23%（OR = 0.77；95% CI：0.66，0.89）。对12项研究的估计值进行线性剂量反应分析表明，膳食钙摄入量每增加100 mg/天，代谢综合征的几率略有显著降低3%（OR = 0.97；95%CI：0.93，1.01）。在对12项研究、67896名参与者进行的非线性剂量反应分析中，发现膳食钙摄入量与代谢综合征之间存在显著关联（P <0.001）；因此，每日500 mg膳食钙摄入量与代谢综合征几率的最大降低相关。根据这项荟萃分析，膳食钙摄入量较高的成年人患代谢综合征的可能性显著较低。需要进一步进行大规模前瞻性队列研究以获得更强有力和更准确的结果。
