Iwasa Z, Yamamoto M, Tanaka A, Okuno K, Sagara N, Matsuda T, Fukuhara T, Yasutomi M
Gan No Rinsho. 1985 Dec;31(15):1865-70.
A comparative study of rat and human mammary tumors was undertaken to clarify the mechanism of hormone dependency by the PAP method. In normal mammary glands, histological estrogen receptor ER (+) cells were observed in the ductal epithelium and acinal cells, while only ER (-) cells were noted in HAN. After overiectomy, 55.6% of the ER (+) cells changes to ER (-). Furthermore, histological changes were glandular atrophy, anaplastic changes, (with) the remaining ER (+) cells (being in the) insular group. Those ER (+) cancer cells seem to be different in hormone sensitivity. As for human mammary glands, proliferation of ER (+) cells was observed in papillary lesions as duct papillomatosis. In the cancer tissues as a whole, ER (+) and ER (-) cancer cells were mixed, showing a so-called mosaic pattern.
采用PAP法对大鼠和人类乳腺肿瘤进行了比较研究，以阐明激素依赖性的机制。在正常乳腺中，在导管上皮和腺泡细胞中观察到组织学雌激素受体ER(+)细胞，而在HAN中仅观察到ER(-)细胞。去卵巢后，55.6%的ER(+)细胞转变为ER(-)。此外，组织学变化为腺体萎缩、间变，剩余的ER(+)细胞呈岛状分布。这些ER(+)癌细胞似乎对激素的敏感性不同。对于人类乳腺，在乳头状病变如导管乳头状瘤病中观察到ER(+)细胞的增殖。在整个癌组织中，ER(+)和ER(-)癌细胞混合存在，呈现所谓的镶嵌模式。
