Inam Zaina, Pan Miao, Diab Yaser, Schore Reuven, Vatsayan Anant, Cheng Jinjun
From the Center for Cancer and Blood Disorders, Children's National Hospital, Washington, DC (Inam, Diab, Schore, Vatsayan, Cheng).
From the Center for the Divisions of Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC (Pan, Cheng).
Arch Pathol Lab Med. 2025 Jul 1;149(7):679-687. doi: 10.5858/arpa.2024-0164-RA.
CONTEXT.—: Myelodysplastic syndromes (MDSs) are rare in children and have unique clinical manifestations and implications.
OBJECTIVE.—: To review the clinical features, pathogenesis, and classification of pediatric MDS.
DATA SOURCES.—: Published literature and personal experience.
CONCLUSIONS.—: Pediatric MDS vastly differs from adult MDS. Evaluation for the presence of an underlying germline predisposition syndrome is critical for optimal classification and management. Because of the rarity of cases, resources to aid with the recognition, diagnosis, and management of pediatric MDS are limited, and multi-institutional collaborative studies are needed for the future.
骨髓增生异常综合征（MDS）在儿童中较为罕见，具有独特的临床表现和影响。
回顾儿童MDS的临床特征、发病机制和分类。
已发表的文献和个人经验。
儿童MDS与成人MDS有很大不同。评估潜在的胚系易感性综合征对于最佳分类和管理至关重要。由于病例罕见，用于识别、诊断和管理儿童MDS的资源有限，未来需要多机构合作研究。
