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LRRK2 is not required for lysozyme expression in Paneth cells.

作者信息

Tasegian Anna, Dikovskaya Dina, Scott Molly M, Chawla Amanpreet Singh, Pemberton Rebecca, Helps Thomas, Meus Tosca, McLean Mairi H, Swamy Mahima

机构信息

Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.

Amphista Therapeutics, Cambridge, UK.

出版信息

Nat Immunol. 2024 Nov;25(11):2037-2039. doi: 10.1038/s41590-024-01972-0. Epub 2024 Oct 8.

DOI:10.1038/s41590-024-01972-0
PMID:39379660
Abstract
摘要

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1
LRRK2 is not required for lysozyme expression in Paneth cells.潘氏细胞中溶菌酶的表达不需要LRRK2。
Nat Immunol. 2024 Nov;25(11):2037-2039. doi: 10.1038/s41590-024-01972-0. Epub 2024 Oct 8.
2
Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells.潘氏细胞中Nod2介导的溶菌酶分选需要Rip2。
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3
Reply to: LRRK2 is not required for lysozyme expression in Paneth cells.回复：潘氏细胞中溶菌酶表达不需要LRRK2 。
Nat Immunol. 2024 Nov;25(11):2040-2042. doi: 10.1038/s41590-024-01968-w. Epub 2024 Oct 8.
4
Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction.巨噬细胞 LRRK2 过度活跃会损害自噬作用，并导致潘氏细胞功能障碍。
Sci Immunol. 2024 Nov 8;9(101):eadi7907. doi: 10.1126/sciimmunol.adi7907.
5
Lysozyme-rich mucus metaplasia in duodenal crypts supersedes Paneth cells in celiac disease.富含溶菌酶的十二指肠隐窝黏液化生取代了乳糜泻中的潘氏细胞。
Virchows Arch. 2011 Sep;459(3):339-46. doi: 10.1007/s00428-011-1129-3. Epub 2011 Jul 18.
6
Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine.潘氏细胞衍生溶菌酶定义了粘液溶解微生物群的组成和肠道的炎症基调。
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[Identification and classification of lysozyme-expressing cells in the mouse small intestinal crypt and their correlation with the morphology of secretory granules and labeling density of immunogold].[小鼠小肠隐窝中表达溶菌酶细胞的鉴定、分类及其与分泌颗粒形态和免疫金标记密度的相关性]
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but not is associated with Paneth cell defect in Japanese Crohn's disease patients.但它与日本克罗恩病患者的潘氏细胞缺陷无关。
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Pouchitis Is Associated with Paneth Cell Dysfunction and Ameliorated by Exogenous Lysosome in a Rat Model Undergoing Ileal Pouch Anal Anastomosis.在回肠储袋肛管吻合术大鼠模型中，袋炎与潘氏细胞功能障碍相关，外源性溶酶体可改善袋炎。
Microorganisms. 2023 Nov 22;11(12):2832. doi: 10.3390/microorganisms11122832.
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LRRK2 and Nod2 promote lysozyme sorting in Paneth cells.富含亮氨酸重复激酶2（LRRK2）和核苷酸结合寡聚化结构域蛋白2（Nod2）促进潘氏细胞中溶菌酶的分选。
Nat Immunol. 2015 Sep;16(9):898-900. doi: 10.1038/ni.3255.

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Gene-environment interactions shape the host-microbial interface in inflammatory bowel disease.基因-环境相互作用塑造了炎症性肠病中的宿主-微生物界面。
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The signature of the small intestinal epithelial and immune cells in health and diseases.健康与疾病状态下小肠上皮细胞和免疫细胞的特征
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Inflammation and IL-4 regulate Parkinson's and Crohn's disease associated kinase LRRK2.

本文引用的文献

1
LRRK2 as a target for modulating immune system responses.LRRK2 作为调节免疫系统反应的靶点。
Neurobiol Dis. 2022 Jul;169:105724. doi: 10.1016/j.nbd.2022.105724. Epub 2022 Apr 12.
2
Interleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Model.白细胞介素-27在人组织来源类器官模型中调节胃肠道上皮屏障功能。
Biology (Basel). 2022 Mar 11;11(3):427. doi: 10.3390/biology11030427.
3
Cells of the human intestinal tract mapped across space and time.人类肠道细胞的时空图谱。
炎症和白细胞介素-4调节帕金森病和克罗恩病相关激酶LRRK2。
EMBO Rep. 2025 May 20. doi: 10.1038/s44319-025-00473-x.
Nature. 2021 Sep;597(7875):250-255. doi: 10.1038/s41586-021-03852-1. Epub 2021 Sep 8.
4
IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes.IL-15 和 PIM 激酶指导肠道上皮内淋巴细胞的代谢编程。
Nat Commun. 2021 Jul 13;12(1):4290. doi: 10.1038/s41467-021-24473-2.
5
Colonic epithelial cathelicidin (LL-37) expression intensity is associated with progression of colorectal cancer and presence of CD8 T cell infiltrate.结肠上皮防御素（LL-37）表达强度与结直肠癌的进展和 CD8 T 细胞浸润的存在相关。
J Pathol Clin Res. 2021 Sep;7(5):495-506. doi: 10.1002/cjp2.222. Epub 2021 May 14.
6
Inflammatory bowel disease and Parkinson's disease: common pathophysiological links.炎症性肠病与帕金森病：共同的病理生理学联系。
Gut. 2021 Feb;70(2):408-417. doi: 10.1136/gutjnl-2020-322429. Epub 2020 Oct 16.
7
An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease.潘氏细胞：回肠克罗恩病的关键更新综述
Front Immunol. 2020 Apr 15;11:646. doi: 10.3389/fimmu.2020.00646. eCollection 2020.
8
The PRIDE database and related tools and resources in 2019: improving support for quantification data.PRIDE 数据库及相关工具和资源在 2019 年的进展：提高定量数据支持。
Nucleic Acids Res. 2019 Jan 8;47(D1):D442-D450. doi: 10.1093/nar/gky1106.
9
A single-cell survey of the small intestinal epithelium.小肠上皮的单细胞调查。
Nature. 2017 Nov 16;551(7680):333-339. doi: 10.1038/nature24489. Epub 2017 Nov 8.
10
Development of phospho-specific Rab protein antibodies to monitor activity of the LRRK2 Parkinson's disease kinase.开发磷酸化特异性 Rab 蛋白抗体以监测 LRRK2 帕金森病激酶的活性。
Biochem J. 2018 Jan 2;475(1):1-22. doi: 10.1042/BCJ20170802.