氧化平衡评分与中老年人群腹主动脉钙化的关系。
Association between oxidative balance score and abdominal aortic calcification among middle-aged and elderly population.
机构信息
Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
School of Nursing and Health, Zhengzhou University, Zhengzhou, Henan, 450052, China.
出版信息
BMC Cardiovasc Disord. 2024 Oct 8;24(1):539. doi: 10.1186/s12872-024-04219-w.
BACKGROUND
The Oxidative Balance Score (OBS) was created to evaluate an individual's overall antioxidant status. The objective of this study was to examine the association between OBS and abdominal aortic calcification (AAC) among individuals aged ≥ 40 years.
METHODS
This population-based cross-sectional study used data from the National Health and Nutrition Examination Survey in 2013-2014 and included adults aged ≥ 40 years. Survey-weighted multivariable logistic and restricted cubic spline models were used to assess the association between OBS and AAC.
RESULTS
Among 2520 participants, 744 were diagnosed with AAC (weighted percentage, 28.13%). Survey-weighted multivariable logistic revealed an inverse association between OBS and AAC [0.98 (0.96, 1.00)], and the nonlinear dose-response relationship was observed. Subgroup analysis and interaction tests revealed that this inverse relationship was consistent across different populations (all P for interaction > 0.05).
CONCLUSIONS
OBS was inversely associated with the prevalence of AAC among individuals aged ≥ 40 years. Maintaining a higher OBS may be beneficial in reducing the burden of AAC.
背景
氧化平衡评分（OBS）旨在评估个体的整体抗氧化状态。本研究旨在探讨 OBS 与年龄≥40 岁人群的腹主动脉钙化（AAC）之间的关联。
方法
本基于人群的横断面研究使用了 2013-2014 年国家健康和营养调查的数据，纳入了年龄≥40 岁的成年人。采用调查加权多变量逻辑回归和限制立方样条模型评估 OBS 与 AAC 之间的关联。
结果
在 2520 名参与者中，744 人被诊断为 AAC（加权百分比，28.13%）。调查加权多变量逻辑回归显示，OBS 与 AAC 呈负相关[0.98（0.96，1.00)]，且存在非线性剂量反应关系。亚组分析和交互检验表明，这种负相关关系在不同人群中是一致的（所有交互检验 P 值均>0.05）。
结论
OBS 与年龄≥40 岁人群的 AAC 患病率呈负相关。保持较高的 OBS 可能有助于降低 AAC 的负担。
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