• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

迷幻蘑菇在中风大鼠模型中的神经保护作用。

Neuroprotective effects of psilocybin in a rat model of stroke.

机构信息

Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan.

School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan.

出版信息

BMC Neurosci. 2024 Oct 8;25(1):49. doi: 10.1186/s12868-024-00903-x.

DOI:10.1186/s12868-024-00903-x
PMID:39379834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11462742/
Abstract

BACKGROUND

Psilocybin is a psychedelic 5HT2A receptor agonist found in "magic mushrooms". Recent studies have indicated that 5HT2A agonists, such as dimethyltryptamine, given before middle cerebral artery occlusion (MCAo), improve staircase behavior, increased BDNF expression, and reduce brain infarction in stroke rats. The objective of this study is to determine the protective effect of psilocybin in cellular and animal models of stroke.

METHODS

Adult male and timed-pregnant Sprague-Dawley rats were used for this study. The neural protective effects of psilocybin were determined in primary rat cortical neurons and adult rats. Rats were subjected to a 60-min middle cerebral artery occlusion. Brain tissues were collected for histological and qRTPCR analysis.

RESULTS

Psilocybin reduced glutamate-mediated neuronal loss in rat primary cortical neuronal cultures. Psilocybin-mediated protection in culture was antagonized by the BDNF inhibitor ANA12. Pretreatment with psilocybin reduced brain infarction and neurological deficits in stroke rats. Early post-treatment with psilocybin improved locomotor behavior, upregulated the expression of MAP2 and synaptophysin, and down-regulated the expression of IBA1 in the stroke brain. ANA12 significantly attenuated psilocybin-mediated reduction in brain infarction and improvements in locomotor behavior.

CONCLUSIONS

Psilocybin reduced brain infarction and improved locomotor behavior in stroke rats; the protective mechanisms involve regulating BDNF expression. Our data support a novel therapeutic approach of psilocybin in stroke.

摘要

背景

裸盖菇素是一种存在于“迷幻蘑菇”中的致幻 5HT2A 受体激动剂。最近的研究表明，5HT2A 激动剂，如二甲色胺，在大脑中动脉闭塞（MCAo）前给予，可以改善阶梯行为、增加 BDNF 表达，并减少中风大鼠的脑梗死。本研究的目的是确定裸盖菇素在中风的细胞和动物模型中的保护作用。

方法

本研究使用成年雄性和定时怀孕的 Sprague-Dawley 大鼠。在原代大鼠皮质神经元和成年大鼠中确定裸盖菇素的神经保护作用。大鼠接受 60 分钟的大脑中动脉闭塞。收集脑组织进行组织学和 qRTPCR 分析。

结果

裸盖菇素减少了谷氨酸介导的大鼠原代皮质神经元培养物中的神经元丢失。BDNF 抑制剂 ANA12 拮抗了裸盖菇素介导的保护作用。预先给予裸盖菇素可减少中风大鼠的脑梗死和神经功能缺损。中风后早期给予裸盖菇素可改善运动行为，上调 MAP2 和突触素的表达，并下调中风大脑中 IBA1 的表达。ANA12 显著减弱了裸盖菇素介导的脑梗死减少和运动行为改善。

结论

裸盖菇素可减少中风大鼠的脑梗死和改善运动行为；保护机制涉及调节 BDNF 表达。我们的数据支持裸盖菇素在中风治疗中的一种新的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/3a405ee8cc92/12868_2024_903_Figf_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/2f8960aef599/12868_2024_903_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/e93bb3c46b11/12868_2024_903_Figb_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/3e386f3d0b78/12868_2024_903_Figc_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/06854ca5844b/12868_2024_903_Figd_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/fff1311c3e7b/12868_2024_903_Fige_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/3a405ee8cc92/12868_2024_903_Figf_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/2f8960aef599/12868_2024_903_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/e93bb3c46b11/12868_2024_903_Figb_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/3e386f3d0b78/12868_2024_903_Figc_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/06854ca5844b/12868_2024_903_Figd_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/fff1311c3e7b/12868_2024_903_Fige_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae11/11462742/3a405ee8cc92/12868_2024_903_Figf_HTML.jpg

相似文献

1
Neuroprotective effects of psilocybin in a rat model of stroke.迷幻蘑菇在中风大鼠模型中的神经保护作用。
BMC Neurosci. 2024 Oct 8;25(1):49. doi: 10.1186/s12868-024-00903-x.
2
Neuroprotective effects of Rosavin via HIF-1α signaling in a rat model of ischemic stroke.迷迭香酸通过缺氧诱导因子-1α信号通路在大鼠缺血性脑卒中模型中的神经保护作用
Phytomedicine. 2025 Jul 13;145:157068. doi: 10.1016/j.phymed.2025.157068.
3
Transcranial direct current stimulation enhances the protective effect of isoflurane preconditioning on cerebral ischemia/reperfusion injury: A new mechanism associated with the nuclear protein Akirin2.经颅直流电刺激增强异氟醚预处理对脑缺血/再灌注损伤的保护作用：与核蛋白Akirin2 相关的新机制。
CNS Neurosci Ther. 2024 Sep;30(9):e70033. doi: 10.1111/cns.70033.
4
Activation of BDNF-TrkB-PI3K-AKT signaling pathway by Tong-Qiao-Huo-Xue Decoction facilitates nerve regeneration and mitigates cerebral ischemia-reperfusion injury.通窍活血汤激活BDNF-TrkB-PI3K-AKT信号通路促进神经再生并减轻脑缺血再灌注损伤。
Phytomedicine. 2025 Sep;145:156966. doi: 10.1016/j.phymed.2025.156966. Epub 2025 Jun 12.
5
Effects of arabinoxylan on BDNF/TrkB/p-CREB signaling pathway in the prefrontal cortex and intestinal microbiome in post-stroke depressed rats.阿拉伯木聚糖对中风后抑郁大鼠前额叶皮质BDNF/TrkB/p-CREB信号通路及肠道微生物群的影响。
BMC Neurosci. 2025 Jul 13;26(1):40. doi: 10.1186/s12868-025-00964-6.
6
Psychedelic-assisted therapy for treating anxiety, depression, and existential distress in people with life-threatening diseases.致幻剂辅助治疗对患有危及生命疾病的人群的焦虑、抑郁和存在性困扰的治疗作用。
Cochrane Database Syst Rev. 2024 Sep 12;9(9):CD015383. doi: 10.1002/14651858.CD015383.pub2.
7
Remote Ischemic Postconditioning Improve Cerebral Ischemia-Reperfusion Injury Induced Cognitive Dysfunction through Suppressing Mitochondrial Apoptosis in Hippocampus via TK/BK/B2R-Mediated PI3K/AKT.远程缺血后处理通过TK/BK/B2R介导的PI3K/AKT抑制海马体中的线粒体凋亡，改善脑缺血再灌注损伤所致的认知功能障碍。
Mol Neurobiol. 2025 Apr 14. doi: 10.1007/s12035-025-04864-y.
8
Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation.脑源性神经营养因子-酪氨酸激酶受体B信号通路在经颅直流电刺激改善大鼠缺血性脑卒中后运动功能及神经可塑性中的作用
Brain Res Bull. 2025 Jan;220:111164. doi: 10.1016/j.brainresbull.2024.111164. Epub 2024 Dec 9.
9
Hydroxysafflor yellow A promotes the proliferation and differentiation of endogenous neural stem cells with neural regenerative effects in ischemic stroke.羟基红花黄色素A促进内源性神经干细胞的增殖和分化，对缺血性中风具有神经再生作用。
Phytomedicine. 2025 Aug;144:156905. doi: 10.1016/j.phymed.2025.156905. Epub 2025 May 30.
10
Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia.红景天苷直接激活 HSC70，揭示了 HSC70 在脑缺血后 BDNF 信号和神经发生中的新作用。
Phytother Res. 2024 Jun;38(6):2619-2640. doi: 10.1002/ptr.8178. Epub 2024 Mar 15.

本文引用的文献

1
Herbal formula PM012 induces neuroprotection in stroke brain.草药配方 PM012 可诱导中风脑的神经保护。
PLoS One. 2023 Feb 22;18(2):e0281421. doi: 10.1371/journal.pone.0281421. eCollection 2023.
2
Decreases in State and Trait Anxiety Post-psilocybin: A Naturalistic, Observational Study Among Retreat Attendees.裸盖菇素使用后状态焦虑和特质焦虑的降低：一项针对静修参与者的自然主义观察性研究。
Front Psychiatry. 2022 Jul 7;13:883869. doi: 10.3389/fpsyt.2022.883869. eCollection 2022.
3
Effect of Psilocybin and Ketamine on Brain Neurotransmitters, Glutamate Receptors, DNA and Rat Behavior.
迷幻蘑菇和氯胺酮对大脑神经递质、谷氨酸受体、DNA 和大鼠行为的影响。
Int J Mol Sci. 2022 Jun 16;23(12):6713. doi: 10.3390/ijms23126713.
4
Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects.在一项健康受试者的双盲安慰剂对照研究中直接比较麦角酸二乙酰胺和裸盖菇素的急性效应。
Neuropsychopharmacology. 2022 May;47(6):1180-1187. doi: 10.1038/s41386-022-01297-2. Epub 2022 Feb 25.
5
Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism.裸盖菇素针对酒精中毒中认知障碍和渴望增加的一种常见分子机制。
Sci Adv. 2021 Nov 19;7(47):eabh2399. doi: 10.1126/sciadv.abh2399. Epub 2021 Nov 17.
6
Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder.迷幻蘑菇疗法可增加重度抑郁症患者的认知和神经灵活性。
Transl Psychiatry. 2021 Nov 8;11(1):574. doi: 10.1038/s41398-021-01706-y.
7
Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects.健康受试者随机、双盲、安慰剂对照交叉研究中，依西酞普兰或安慰剂预处理后，裸盖菇素的急性效应。
Clin Pharmacol Ther. 2022 Apr;111(4):886-895. doi: 10.1002/cpt.2487. Epub 2021 Nov 22.
8
Psilocybin for End-of-Life Anxiety Symptoms: A Systematic Review and Meta-Analysis.用于临终焦虑症状的裸盖菇素：一项系统评价与荟萃分析
Psychiatry Investig. 2021 Oct;18(10):958-967. doi: 10.30773/pi.2021.0209. Epub 2021 Oct 8.
9
Dose effect of psilocybin on primary and secondary depression: a preliminary systematic review and meta-analysis.迷幻蘑菇素对原发性和继发性抑郁的剂量效应：一项初步的系统评价和荟萃分析。
J Affect Disord. 2022 Jan 1;296:26-34. doi: 10.1016/j.jad.2021.09.041. Epub 2021 Sep 17.
10
Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics.神经可塑性作为氯胺酮和经典迷幻剂的汇聚机制。
Trends Pharmacol Sci. 2021 Nov;42(11):929-942. doi: 10.1016/j.tips.2021.08.003. Epub 2021 Sep 24.