Department of Nuclear Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, China.
Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, 310027, China.
BMC Med Imaging. 2024 Oct 8;24(1):269. doi: 10.1186/s12880-024-01446-7.
'Kimura's disease (KD) is a rare chronic inflammatory disorder of unknown etiology and is difficult to diagnose due to poor clinical presentation and imaging features. Few studies on characteristics of F-FDG PET/CT of KD have been reported. This study aimed to observe the reliable characteristics and usefulness of F-FDG PET/CT for the evaluation of consecutive patients with KD.
The clinical data and F-FDG PET/CT imaging findings of 8 patients with pathologically confirmed KD were reviewed retrospectively.F-FDG PET/CT images were evaluated visually and semiquantitatively by measuring the maximum standardized uptake value (SUV). The correlations between clinical data and F-FDG PET/CT features were analyzed by simple linear regression.
This study included 7 males and one female ranging in age from 17 to 79 years. The longest diameter of lesions ranged from 0.8 cm to 4.8 cm, and regional or generalized lymphadenopathy was found in all 8 patients with eosinophilia, while subcutaneous masses and salivary gland involvement concurrently were found in 4 patients. F-FDG PET/CT revealed that these involved lesions had high F-FDG uptake with SUV > 2.5 (2.6 to 6.3). Moreover, the margin of the lesions was well defined in 6 cases and ill defined in 2 cases, and homogeneous density and F-FDG uptake were both found in all these lesions. There was negative correlation between eosinophils and SUV (R = 0.538).
Kimura's disease should be considered when F-FDG PET/CT is characterized by homogeneous lesions of regional or generalized lymphadenopathy, accompanied with subcutaneous masses and salivary gland involvement concurrently, especially in patients with eosinophilia.
木村病（KD）是一种罕见的慢性炎症性疾病，病因不明，由于临床表现和影像学特征较差，诊断困难。关于 KD 的 F-FDG PET/CT 特征的研究较少。本研究旨在观察 F-FDG PET/CT 对连续 KD 患者评估的可靠特征和实用性。
回顾性分析 8 例经病理证实的 KD 患者的临床资料和 F-FDG PET/CT 影像学表现。通过测量最大标准化摄取值（SUV）对 F-FDG PET/CT 图像进行视觉和半定量评估。通过简单线性回归分析临床数据与 F-FDG PET/CT 特征之间的相关性。
本研究包括 7 名男性和 1 名女性，年龄 17 至 79 岁。病变最长径 0.8 至 4.8cm，8 例患者均有区域性或全身性淋巴结病和嗜酸性粒细胞增多，4 例患者同时有皮下肿块和唾液腺受累。F-FDG PET/CT 显示这些受累病灶 F-FDG 摄取高，SUV＞2.5（2.6 至 6.3）。此外，6 例病灶边界清楚，2 例边界不清楚，所有病灶均为均匀密度和 F-FDG 摄取。嗜酸性粒细胞与 SUV 呈负相关（R=0.538）。
当 F-FDG PET/CT 表现为区域性或全身性淋巴结病、伴发皮下肿块和唾液腺受累，特别是伴有嗜酸性粒细胞增多时，应考虑木村病。
