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大规模肠切除调节大鼠体内参与脂质和胆固醇代谢的基因表达。

Massive bowel resection modulates the expression of genes involved in lipid and cholesterol metabolism in rats.

作者信息

Hebiguchi Taku, Morii Mayako, Watanabe Ryo, Yoshino Hiroaki, Mezaki Yoshihiro

机构信息

Department of Pediatric Surgery, Akita University Graduate School of Medicine, Akita-city, Akita, Japan.

Department of Pediatric Surgery, Akita Kousei Medical Center, Akita-city, Akita, Japan.

出版信息

MicroPubl Biol. 2024 Sep 6;2024. doi: 10.17912/micropub.biology.001253. eCollection 2024.

DOI:10.17912/micropub.biology.001253
PMID:39381641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11461028/
Abstract

We have previously shown that vitamin A-absorptive function was enhanced in bowel-resected rats via increased expression of cellular retinol-binding protein II (CRBP II). Recently, CRBP II was shown to bind not only to retinol but also to monoacylglycerols to modulate gut endocrine signaling. We hypothesized that the increased CRBP II in bowel-resected rats had broader effects than vitamin A metabolism. Acetyl-CoA carboxylase 1 (fatty-acid biosynthesis) and sterol O-acyltransferase 1 (cholesterol esterification) expressions were down-regulated in the bowel-resected rats. Adjustment of nutritional absorption may take place in a limited area of the small intestine by the modulation of gene expression.

摘要

我们之前已经表明，通过增加细胞视黄醇结合蛋白II（CRBP II）的表达，肠道切除大鼠的维生素A吸收功能得到增强。最近研究表明，CRBP II不仅与视黄醇结合，还与单酰甘油结合以调节肠道内分泌信号。我们推测，肠道切除大鼠体内CRBP II的增加所产生的影响比维生素A代谢更为广泛。肠道切除大鼠体内的乙酰辅酶A羧化酶1（脂肪酸生物合成）和固醇O-酰基转移酶1（胆固醇酯化）的表达下调。营养吸收的调节可能通过基因表达的调控在小肠的有限区域内发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a7/11461028/e2b0f1ae01e0/25789430-2024-micropub.biology.001253.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a7/11461028/e2b0f1ae01e0/25789430-2024-micropub.biology.001253.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a7/11461028/e2b0f1ae01e0/25789430-2024-micropub.biology.001253.jpg

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本文引用的文献

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Management of pediatric intestinal failure related to short bowel syndrome.小儿短肠综合征相关肠衰竭的管理。
Semin Pediatr Surg. 2022 Jun;31(3):151175. doi: 10.1016/j.sempedsurg.2022.151175. Epub 2022 May 14.
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Genetic, biochemical, and clinical features of LCAT deficiency: update for 2020.卵磷脂胆固醇酰基转移酶缺乏症的遗传、生化及临床特征：2020年更新
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Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight.
视黄醇结合蛋白 2（RBP2）结合单酰甘油，调节肠道内分泌信号和体重。
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