Linkage of the alpha G Philadelphia locus to alpha-thalassemia in the Cuban population.

The inheritance of the alpha-chain hemoglobin variant G Philadelphia was studied in three Cuban families of African ancestry. The variant represented approximately 33% of the total adult hemoglobin in all subjects, and was associated to a 10.5 kb Bam HI restriction fragment. Mild hematological alterations were present. These data indicate that also in the Cuban population the alpha G Philadelphia locus is linked to a deletional alpha-thalassemia.