Zhang Emily S, Doty Samuel, Woody Neil, Bottalico Danielle, Ku Jamie A, Prendes Brandon, Koyfman Shlomo A, Campbell Shauna R, Silver Natalie, Scharpf Joseph, Lamarre Eric D
Cleveland Clinic Head and Neck Institute Cleveland USA.
Case Western Reserve University School of Medicine Cleveland USA.
OTO Open. 2024 Oct 8;8(4):e70030. doi: 10.1002/oto2.70030. eCollection 2024 Oct-Dec.
Minor salivary gland carcinomas are challenging to study due to their rarity and heterogeneity. We aim to further characterize clinical characteristics, treatment, and outcomes over 20 years within a single institution.
Retrospective chart review was conducted on 210 patients who received primary treatment for minor salivary gland malignancy from 2000 to 2022.
Single tertiary-care center.
Multivariable Cox proportional hazards method was used to examine the relationship between pre-determined clinically important variables and outcomes.
Five-year overall survival was 77.8% (72.0-84.1). Advanced clinical T stage portended over a 2 times higher risk of death and recurrence. High pathologic grade was associated with a near 3 times higher risk of death and recurrence. There was a predominance of occult nodal metastases in level II for oral cavity and oropharynx site tumors.
Clinical T stage and grade were important for overall survival, local, regional, and distant recurrence-free survival. Occult nodal metastases occurred most often in level II.
小涎腺癌因其罕见性和异质性，研究颇具挑战性。我们旨在进一步描述单一机构内20年间的临床特征、治疗及预后情况。
对2000年至2022年期间接受小涎腺恶性肿瘤初始治疗的210例患者进行回顾性病历审查。
单一三级医疗中心。
采用多变量Cox比例风险法来检验预先确定的具有临床重要性的变量与预后之间的关系。
五年总生存率为77.8%（72.0 - 84.1）。临床T分期较晚预示死亡和复发风险高出2倍以上。高病理分级与死亡和复发风险高出近3倍相关。口腔和口咽部位肿瘤在Ⅱ区隐匿性淋巴结转移占主导。
临床T分期和分级对总生存率、局部、区域和远处无复发生存率很重要。隐匿性淋巴结转移最常发生在Ⅱ区。
