Department of Psychiatry, GCS Medical College, Hospital and Research Centre, Gujarat, 380025, India.
Department of Medicine, Icahn School of Medicine at Mount Sinai, NYC Health + Hospitals, Queens,New York, NY 11432, USA.
Future Cardiol. 2024;20(13):709-718. doi: 10.1080/14796678.2024.2408944. Epub 2024 Oct 9.
Bipolar disorder is a severe and recurring condition that has become a significant public health issue globally. Studies indicate a heightened risk and earlier onset of cardiovascular diseases among individuals with bipolar disorder, potentially increasing mortality rates. The chronic nature of bipolar disorder leads to disturbances across multiple systems, including autonomic dysfunction, over-activation of the hypothalamic-pituitary-adrenal axis and increased levels of peripheral inflammatory markers. These disruptions cause endothelial damage, the formation of plaques and blood clots, in addition to the medications used to treat bipolar disorder and genetic associations contributing to cardiovascular disease development. Understanding the complex interplay between bipolar disorder and cardiovascular events is essential for the prevention and effective management of cardiovascular conditions in individuals with bipolar disorder.
双相情感障碍是一种严重且反复发作的疾病，已成为全球范围内的重大公共卫生问题。研究表明，双相情感障碍患者的心血管疾病风险增加，发病更早，可能会导致死亡率上升。双相情感障碍的慢性特征会导致多个系统出现紊乱，包括自主神经功能障碍、下丘脑-垂体-肾上腺轴过度活跃和外周炎症标志物水平升高。这些紊乱会导致内皮细胞损伤、斑块形成和血栓形成，此外，用于治疗双相情感障碍的药物以及导致心血管疾病发展的遗传关联也会产生影响。了解双相情感障碍和心血管事件之间的复杂相互作用对于预防和有效管理双相情感障碍患者的心血管疾病至关重要。
