VA South Central Mental Illness Research, Education & Clinical Center, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.
Houston VA HSR&D Center for Innovations in Quality, Effectiveness & Safety, Michael E. DeBakey VA Medical Center, Houston, TX 77021, USA.
Pharmacogenomics. 2024;25(12-13):495-501. doi: 10.1080/14622416.2024.2409058. Epub 2024 Oct 9.
To survey Veterans Health Administration providers who prescribed tramadol or codeine to patients with known genotyping for cytochrome 2D6 () to ascertain awareness of their patient's pharmacogenetic (PGx) test status, whether these results influenced prescribing, perceived benefit of PGx testing, and resources needed to obtain and deliver PGx testing information. A provider survey was conducted of those who prescribed tramadol or codeine in a patient genotyped for . Of 876 eligible providers, 220 completed the survey. Ten percent were aware that their patient received a PGx test, 64% had not ordered any PGx test related to any medication in the prior year, 55% strongly agreed or agreed that PGx testing is or will be valuable to guide pain medication prescriptions, 29% felt that the evidence base for PGx testing is very strong or moderately strong, 22% responded likely or extremely likely to order a future PGx test, and 51% felt that it would be either very important or fairly important to have a local subject matter expert as a resource for PGx testing. There are modifiable factors that the Veterans Health Administration could address to optimize PGx testing for pain management.
为了调查为已知细胞色素 2D6（）基因分型的患者开曲马多或可待因的退伍军人健康管理局（Veterans Health Administration）医务人员，以了解他们对患者药物遗传学（PGx）检测结果的知晓情况，以及这些结果是否影响处方、对 PGx 检测益处的看法，以及获取和提供 PGx 检测信息所需的资源。对为进行过基因分型的患者开具曲马多或可待因处方的医务人员进行了一项提供者调查。在 876 名符合条件的提供者中，有 220 名完成了调查。10%的人知道他们的患者接受了 PGx 检测，64%的人在过去一年中没有开任何与任何药物相关的 PGx 检测，55%的人强烈或同意 PGx 检测对指导疼痛药物处方具有价值，29%的人认为 PGx 检测的证据基础非常强或中等强，22%的人表示可能或极有可能在未来开 PGx 检测，51%的人认为拥有当地的主题专家作为 PGx 检测资源非常重要或相当重要。退伍军人健康管理局可以解决一些可改变的因素，以优化疼痛管理的 PGx 检测。
