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组胺与黑貂(鼬属)的继发性自身免疫性不育

Histamine and secondary autoimmune infertility in dark mink (Mustela vison).

作者信息

Nemetallah B R, Howell R E, Ellis L C

出版信息

Arch Androl. 1985;15(1):79-82. doi: 10.3109/01485018508986895.

DOI:10.3109/01485018508986895
PMID:3938204
Abstract

Testicular histamine content was higher in December (the time of sexual quiescence) that in March (breeding time) in opaline mink. Although testicular histamine synthesis increased in March over December, the increased cellular mass and increased histaminase activity prevented the biogenic amine from rising. Dark mink, however, had higher gonadal levels of histamine in March than in December owing to an increased rate of synthesis and a decreased rate of inactivation that correlated well with the onset of autoimmune infertility in this strain. Pastel mink were intermediate to the opalines, and dark mink indicative of strain differences in the genetic control of gonadal histamine synthesis and inactivation.

摘要

在蛋白石貂中,睾丸组胺含量在12月(性静止期)高于3月(繁殖期)。尽管3月睾丸组胺合成较12月有所增加,但细胞数量增加和组胺酶活性增强阻止了生物胺含量升高。然而,深色貂3月性腺中的组胺水平高于12月,这是由于合成速率增加和失活速率降低,这与该品系自身免疫性不育的发生密切相关。浅色貂的情况介于蛋白石貂和深色貂之间,表明在性腺组胺合成和失活的遗传控制方面存在品系差异。

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