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一种新型的机器人根治性前列腺切除术前路手术方法与传统方法相比,能使患者更早恢复控尿功能。

A novel anterior approach toward robotic radical prostatectomy is associated with earlier continence recovery than the conventional approach.

作者信息

Washino Satoshi, Saito Kimitoshi, Yazaki Kai, Miyagawa Tomoaki

机构信息

Department of Urology, Jichi Medical University Saitama Medical Center, Saitama, Japan.

出版信息

Int J Urol. 2025 Jan;32(1):80-87. doi: 10.1111/iju.15599. Epub 2024 Oct 9.

Abstract

OBJECTIVES

To advance robotic radical prostatectomy, we developed a novel anterior approach that uses a peritoneal incision created between the umbilical ligaments to develop the Retzius space and thus spares vessels that surround the bladder and prostate, with the space being closed after prostatectomy and vesicourethral anastomosis. This approach may improve continence recovery. We investigated continence recovery following the novel anterior approach compared to after the conventional anterior approach.

METHODS

We retrospectively reviewed 516 patients who underwent robotic radical prostatectomy from January 2019 to July 2023. We compared continence recovery following our novel anterior approach (N = 282) to that after conventional anterior approach (N = 234), and we compared the oncological outcomes and safety profiles of the two groups.

RESULTS

Patient demographics did not differ significantly between the two groups. Continence recovery in patients undergoing the novel anterior approach was significantly better than that of patients treated via the conventional approach (hazard ratio: 1.651, 95% confidence interval: 1.325-2.057, p < 0.0001). Use of the novel anterior approach in addition to nerve sparing and preservation of the detrusor apron independently predicted continence, and the mixture of these three techniques afforded excellent continence recovery (1- and 2-year total continence rate of 81.1% and 93.7%). Neither the biochemical recurrence-free survival nor the complication rate differed significantly between the two groups.

CONCLUSION

Our novel anterior approach may improve continence recovery compared to the conventional anterior approach, without compromising the oncological outcomes. Prospective comparative studies are necessary to confirm the benefits of this approach.

摘要

目的

为推进机器人根治性前列腺切除术,我们开发了一种新型前路手术方法,该方法通过在脐韧带之间做腹膜切口来分离Retzius间隙,从而保留膀胱和前列腺周围的血管,在前列腺切除及膀胱尿道吻合术后关闭该间隙。这种方法可能会改善控尿功能的恢复。我们研究了新型前路手术方法与传统前路手术方法相比在控尿功能恢复方面的情况。

方法

我们回顾性分析了2019年1月至2023年7月期间接受机器人根治性前列腺切除术的516例患者。我们将新型前路手术方法组(N = 282)与传统前路手术方法组(N = 234)的控尿功能恢复情况进行了比较,并比较了两组的肿瘤学结局和安全性。

结果

两组患者的人口统计学特征无显著差异。采用新型前路手术方法的患者控尿功能恢复明显优于采用传统手术方法的患者(风险比:1.651,95%置信区间:1.325 - 2.057,p < 0.0001)。除保留神经和保留逼尿肌围裙外,采用新型前路手术方法可独立预测控尿功能,这三种技术联合应用可实现极佳的控尿功能恢复(1年和2年的完全控尿率分别为81.1%和93.7%)。两组的无生化复发生存率和并发症发生率均无显著差异。

结论

与传统前路手术方法相比,我们的新型前路手术方法可能会改善控尿功能恢复,且不影响肿瘤学结局。需要进行前瞻性对照研究以证实该方法的益处。

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