Clin Lab. 2024 Oct 1;70(10). doi: 10.7754/Clin.Lab.2024.240216.
Vitamin D is a fat-soluble vitamin found in two forms, sourced either from plants (D2) or animals (D3). Numerous epidemiological studies worldwide have highlighted its deficiency across diverse populations in various countries. When coupled with obesity, this deficiency becomes a significant global health concern. Our study aimed to evaluate the vitamin D levels among obese individuals in Southern Morocco.
This is a retrospective, cross-sectional descriptive study on the vitamin D status in obese subjects. This study was conducted at the "Health Universe" Diet Center in Agadir, Morocco. The measurement method involved using a Tanita® wall-mounted metal stadiometer to determine height and a Tanita® BC 418 MA segmental body composition analyzer to determine weight. The serum level of 25-hydroxyvitamin D was determined by elec-trochemiluminescence (ECLIA) using the Elecsys® and Cobas e411®.
The sample of our study, consisting of 1,210 individuals, is composed of 73.5% (n = 889) females and 26.5% (n = 321) males. The mean age of the entire sample is 42.3 ± 13.1 years (ranging from 18 to 86 years). The mean BMI is 37 ± 5.69 kg/m², with a higher value in females (37.4 ± 5.85 kg/m²) compared to males (35.7 ± 5.03 kg/m²), including 42.8% moderate obesity, 34.2% severe obesity, and 23% morbid obesity. The mean serum vitamin D level in our sample is 15.7 ± 7.67 ng/mL. This level is 14.5 ± 7.42 ng/mL for females and 19.2 ± 7.31 ng/mL for males. However, only 5.3% of the subjects have an adequate serum vitamin D level, while 18% have an insufficiency, 52.5% have a moderate deficiency, and 24.2% have a severe deficiency. An inverse trend was noted for BMI, which shows a very significant inverse correlation with serum vitamin D concentration (r = -0.18 and p < 0.01).
Our results support the hypothesis that obesity is inversely associated with low vitamin D levels. Lifestyle improvement should be considered as the primary treatment option, aiming to enhance the dysmetabolic state associated with obesity and vitamin D deficiency.
维生素 D 是一种脂溶性维生素，有两种形式，一种来自植物（D2），另一种来自动物（D3）。全球许多流行病学研究都强调了在不同国家的不同人群中存在维生素 D 缺乏的现象。当与肥胖结合时，这种缺乏就成为了一个重大的全球健康问题。我们的研究旨在评估摩洛哥南部肥胖人群的维生素 D 水平。
这是一项在摩洛哥阿加迪尔的“健康宇宙”减肥中心进行的回顾性、横断面描述性研究，评估肥胖人群的维生素 D 状态。使用 Tanita®壁挂式金属测高仪测量身高，Tanita® BC 418 MA 分段体成分分析仪测量体重来确定维生素 D 状态。采用电化学发光（ECLIA）法，使用 Elecsys®和 Cobas e411®测定血清 25-羟维生素 D 水平。
我们的研究样本由 1210 人组成，其中 73.5%（n=889）为女性，26.5%（n=321）为男性。整个样本的平均年龄为 42.3±13.1 岁（18-86 岁）。平均 BMI 为 37±5.69kg/m²，女性（37.4±5.85kg/m²）高于男性（35.7±5.03kg/m²），包括 42.8%中度肥胖、34.2%重度肥胖和 23%病态肥胖。我们样本的平均血清维生素 D 水平为 15.7±7.67ng/ml，女性为 14.5±7.42ng/ml，男性为 19.2±7.31ng/ml。然而，仅有 5.3%的研究对象血清维生素 D 水平充足，18%不足，52.5%存在中度缺乏，24.2%存在严重缺乏。BMI 呈负相关趋势，与血清维生素 D 浓度呈显著负相关（r=-0.18，p<0.01）。
我们的研究结果支持肥胖与低维生素 D 水平呈负相关的假设。生活方式的改善应被视为主要的治疗选择，以改善与肥胖和维生素 D 缺乏相关的代谢异常状态。
