Fleischman J B
Biosci Rep. 1985 Oct-Nov;5(10-11):893-9. doi: 10.1007/BF01119901.
Rodney Porter's separation of antibody molecules into Fab and Fc fragments engendered the notion that a single antibody polypeptide chain might be coded by two or more genes. This concept profoundly influenced the development of molecular immunology over the past 25 years. Our current knowledge of antibody gene organization has enabled investigators to recombine antibody genes to create 'chimeric' antibodies with a number of potentially useful applications.
罗德尼·波特将抗体分子分离为Fab和Fc片段，引发了一种观点，即单个抗体多肽链可能由两个或更多基因编码。这一概念在过去25年中对分子免疫学的发展产生了深远影响。我们目前对抗体基因组织的了解使研究人员能够重组抗体基因，以创造出具有许多潜在有用应用的“嵌合”抗体。
