Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China; Zhejiang China Resources Sanjiu Zhongyi Pharmaceutical Co., Ltd., Lishui 323010, China.
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Eur J Pharm Biopharm. 2024 Nov;204:114527. doi: 10.1016/j.ejpb.2024.114527. Epub 2024 Oct 9.
The efficient and secure delivery of intravenous chemotherapeutic agents across the blood-brain barrier (BBB) to the precise location of a brain tumor is a crucial element in glioma treatment. Herein, we introduce a biomimetic nanoplatform (T7-M-C/S) comprising a core made up of irinotecan hydrochloride (CPT11) and its bioactive metabolite, 7-Ethyl-10-hydroxycamptothecin (SN38), surrounded by a layer of T7-peptide-modified macrophage membrane. CPT11 spontaneously assembles with SN38 into stable and water-dispersible nanoparticles (C/S), greatly enhancing the water solubility of SN38. The integration of the modified peptide with the inherent proteins expressed by macrophage cells confers the nanoplatform with enhanced bioavailability and robust glioma-targeting abilities, ultimately resulting in superior therapeutic outcomes. These discoveries highlight a drug delivery system characterized by a high drug loading capacity, leveraging the macrophage membrane, and promising significant potential for glioma treatment.
高效且安全地将静脉化疗药物递送至血脑屏障（BBB）内的脑瘤精确位置，是神经胶质瘤治疗的关键环节。在此，我们引入了一种仿生纳米平台（T7-M-C/S），它由核心部分组成，包括盐酸伊立替康（CPT11）及其生物活性代谢物 7-乙基-10-羟基喜树碱（SN38），并被一层 T7 肽修饰的巨噬细胞膜所包围。CPT11 与 SN38 会自发组装成稳定且可分散在水中的纳米颗粒（C/S），极大地提高了 SN38 的水溶性。经修饰的肽与巨噬细胞表达的固有蛋白的整合，赋予了纳米平台更高的生物利用度和强大的神经胶质瘤靶向能力，最终实现了卓越的治疗效果。这些发现突显了一种具有高载药能力、利用巨噬细胞膜的药物递送系统，为神经胶质瘤治疗带来了广阔的前景。
