Laboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, Universidad de Extremadura, Cáceres, Spain.
Laboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, Universidad de Extremadura, Cáceres, Spain.
J Equine Vet Sci. 2024 Dec;143:105204. doi: 10.1016/j.jevs.2024.105204. Epub 2024 Oct 9.
Although stallion spermatozoa are now recognized as highly dependent on oxidative phosphorylation for ATP production in the mitochondria, most extenders in use contain supraphysiological concentrations of glucose as the main energy source. While the toxicity of cryoprotectants has been well documented in the literature, the potential toxicity of excessive glucose in extenders is largely ignored. However, the toxicity of excess glucose, known as "carbotoxicity", is well-established in many areas of medicine. In this paper, we review the basic aspects of stallion spermatozoa metabolism, focusing on factors that significantly impact the lifespan and functionality of spermatozoa during conservation.
尽管现在已经认识到种马精子的 ATP 产生高度依赖于线粒体中的氧化磷酸化，但大多数使用的稀释液中含有超生理浓度的葡萄糖作为主要能量来源。虽然冷冻保护剂的毒性在文献中已有充分记载，但在很大程度上忽略了稀释液中过量葡萄糖的潜在毒性。然而，过量葡萄糖的毒性，即“糖毒性”，在许多医学领域已经得到充分证实。在本文中，我们综述了种马精子代谢的基本方面，重点介绍了在保存过程中对精子寿命和功能有重大影响的因素。
