Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, Yunnan, P. R. China.
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, Yunnan, P. R. China.
Alkaloids Chem Biol. 2024;92:47-119. doi: 10.1016/bs.alkal.2024.08.001. Epub 2024 Sep 24.
The sarpagine-ajmaline type monoterpenoid indole alkaloids are among the most important groups of natural alkaloids, and the complex polycyclic and cage-like architectures present significant synthetic challenges. Because of their characteristic indole-fused azabicyclo[3.3.1]nonane structures and prominent biological activities, sarpagine-ajmaline related alkaloids have captured the attention of organic synthetic chemists for decades. In this chapter, the strategies employed in the synthesis of sarpagine-ajmaline related alkaloids are outlined, and the synthetic progress during the period of 2019-2023 is provided in detail. To provide potential targets for future synthetic endeavors, some sarpagine/ajmaline type alkaloids isolated in recent years with novel structures and biological activities are also summarized.
薤白-阿马林型单萜吲哚生物碱是最重要的天然生物碱群之一，其复杂的多环和笼状结构带来了重大的合成挑战。由于其特征性的吲哚稠合氮杂双环[3.3.1]壬烷结构和突出的生物活性，薤白-阿马林相关生物碱吸引了有机合成化学家数十年的关注。本章概述了合成薤白-阿马林相关生物碱所采用的策略，并详细介绍了 2019-2023 年期间的合成进展。为了为未来的合成努力提供潜在目标，还总结了近年来分离得到的具有新颖结构和生物活性的一些薤白/阿马林型生物碱。
