接触农药与2型糖尿病风险的关系：一项系统评价与荟萃分析
Impact of pesticides exposure and type 2 diabetes risk: a systematic review and meta-analysis.
作者信息
Chen Yang, Deng Yaqin, Wu Minjia, Ma Peixuan, Pan Wen, Chen Weiqi, Zhao Lina, Huang Xiaowei
机构信息
Department of Toxicology, School of Public Health, Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, China.
Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China.
出版信息
Endocrine. 2025 Feb;87(2):448-458. doi: 10.1007/s12020-024-04067-w. Epub 2024 Oct 9.
OBJECTIVE
We conducted a systematic review and meta-analysis of observational studies that assessed the relationship between pesticides exposure and type 2 diabetes. We also examined the presence of heterogeneity and biases across the available studies.
METHODS
We conducted a comprehensive literature search of peer-reviewed studies published from 2011 to 2023, without language limitations. A random-effects model was employed to calculate the overall odds ratio (OR) and its corresponding 95% confidence interval (CI).
RESULTS
We included 19 studies (n = 12 case-control and n = 7 cross-sectional) for a total of 45,813 participants in our analysis. Our findings revealed a notable correlation between pesticide exposure and type 2 diabetes (non-specific definition) when not limiting pesticide types (OR: 1.19, 95% CI: 1.11-1.28). Subgroup analysis identified associations between pyrethroid (OR: 1.17, 95% CI: 1.05-1.30) and type 2 diabetes, as well as between organochlorine (OR: 1.26, 95% CI: 1.11-1.43) and type 2 diabetes. However, no statistically significant association was observed between herbicide exposure and the onset of type 2 diabetes (OR: 1.26, 95% CI: 0.91-1.75). In the elderly group, pesticide exposure significantly heightened the risk of type 2 diabetes (OR: 1.25, 95% CI: 1.14-1.38), with no statistically significant heterogeneity among studies (I = 14.2%, p = 0.323).
CONCLUSIONS
Pesticide (organochlorine and pyrethroid) exposure constitutes a risk factor for type 2 diabetes.
目的
我们对评估农药暴露与2型糖尿病之间关系的观察性研究进行了系统评价和荟萃分析。我们还研究了现有研究中异质性和偏倚的存在情况。
方法
我们对2011年至2023年发表的同行评审研究进行了全面的文献检索，无语言限制。采用随机效应模型计算总体比值比（OR）及其相应的95%置信区间（CI）。
结果
我们纳入了19项研究（12项病例对照研究和7项横断面研究），分析中共有45813名参与者。我们的研究结果显示，在不限制农药类型时，农药暴露与2型糖尿病（非特定定义）之间存在显著相关性（OR：1.19，95%CI：1.11 - 1.28）。亚组分析确定了拟除虫菊酯（OR：1.17，95%CI：1.05 - 1.30）与2型糖尿病之间以及有机氯（OR：1.26，95%CI：1.11 - 1.43）与2型糖尿病之间的关联。然而，未观察到除草剂暴露与2型糖尿病发病之间存在统计学显著关联（OR：1.26，95%CI：0.91 - 1.75）。在老年组中，农药暴露显著增加了2型糖尿病的风险（OR：1.25，95%CI：1.14 - 1.38），各研究之间无统计学显著异质性（I² = 14.2%，p = 0.323）。
结论
农药（有机氯和拟除虫菊酯）暴露是2型糖尿病的一个危险因素。
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