Dudler Julie, Chuard Christian
Service de médecine interne, HFR Fribourg, 1752 Villars-sur-Glâne.
Service d'infectiologie, HFR Fribourg, 1752 Villars-sur-Glâne.
Rev Med Suisse. 2024 Oct 9;20(890):1805-1809. doi: 10.53738/REVMED.2024.20.890.1805.
Candida spp is responsible for 70-90% of invasive fungal infections. Invasive candidiasis is usually diagnosed by blood culture; other microbiological methods such as PCR, beta-D-glucans and mannans/anti-mannans are available in addition to clinical scores such as the Candida score. Management includes antifungal therapy, removal of catheters and source control, follow-up blood cultures and fundus examination, one possible complication being endophthalmitis. Candida albicans is the most common species in Switzerland and is generally susceptible to all antifungal agents. One concern is the spread of Candida auris, due to multi-resistant strains and the propensity to spread within and between hospitals, which is difficult to control.
念珠菌属导致70%-90%的侵袭性真菌感染。侵袭性念珠菌病通常通过血培养诊断；除了念珠菌评分等临床评分外，还有其他微生物学方法，如聚合酶链反应（PCR）、β-D-葡聚糖和甘露聚糖/抗甘露聚糖检测。治疗包括抗真菌治疗、拔除导管和源头控制、后续血培养和眼底检查，一种可能的并发症是眼内炎。白色念珠菌是瑞士最常见的念珠菌种类，通常对所有抗真菌药物敏感。一个令人担忧的问题是耳念珠菌的传播，因其具有多重耐药菌株且易于在医院内部和医院之间传播，难以控制。
