Department of Chemistry, School for Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Department of Forensic Sciences, School for Bioengineering and Biosciences Sciences, Lovely Professional University, Phagwara, Punjab, India.
J Mater Chem B. 2024 Nov 6;12(43):11076-11088. doi: 10.1039/d4tb01930j.
The convergence of nanotechnology and cancer therapeutics has opened new frontiers in the development of advanced drug delivery systems. Among the various nanocarriers, nanobubbles offer significant potential due to their unique properties, such as high payload capacity, responsiveness to external stimuli like ultrasound, and enhanced permeability and retention (EPR) effects. Functionalizing these nanobubbles with chitosan, a naturally derived biopolymer known for its biocompatibility, biodegradability, and ability to enhance cellular uptake, further improves their therapeutic efficacy. This review provides a comprehensive analysis of the synthesis, functionalization, and application of chitosan-functionalized nanobubbles in cancer therapy. We discuss their mechanism of action, including targeted drug delivery, ultrasound-mediated release, and immune modulation, alongside recent advancements and challenges in their clinical translation. This review also explores future directions in this rapidly evolving field, aiming to offer insights into the development of next-generation cancer therapeutics.
纳米技术和癌症治疗学的融合为先进药物输送系统的发展开辟了新的前沿。在各种纳米载体中，纳米气泡因其独特的性质，如高载药能力、对超声等外部刺激的响应性以及增强的通透性和保留（EPR）效应，具有显著的潜力。通过壳聚糖对这些纳米气泡进行功能化，壳聚糖是一种具有生物相容性、可生物降解性和增强细胞摄取能力的天然生物聚合物，进一步提高了它们的治疗效果。本综述全面分析了壳聚糖功能化纳米气泡在癌症治疗中的合成、功能化和应用。我们讨论了它们的作用机制，包括靶向药物输送、超声介导释放和免疫调节，以及它们在临床转化中的最新进展和挑战。本综述还探讨了这个快速发展领域的未来方向，旨在为下一代癌症治疗药物的开发提供思路。
