Virú-Loza Manuel André
Unidad de Revisiones Sistemáticas y Meta-análisis, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, Peru.
SAGE Open Med Case Rep. 2024 Oct 8;12:2050313X241275445. doi: 10.1177/2050313X241275445. eCollection 2024.
Surgical treatment of craniopharyngiomas in children can produce disorders related to water and sodium such as central diabetes insipidus (CDI) and cerebral salt wasting syndrome (CSWS). The combination of both in children is unusually reported in the literature and is associated with high mortality. The management of CSWS is based on fluid therapy. Fludrocortisone is useful in children with CSWS who do not respond to fluid management. The objective of the paper is to describe the case of 6 years and 10 months old male child with hypopituitarism secondary to a craniopharyngioma surgery performed 7 months before, who presented to the emergency department due to recurrent craniopharyngioma. The child presented a combination of CDI and CSWS following surgery for this recurrent tumor. Therapy with fludrocortisone was effective. Pediatric patients as the one of this report can help build the foundation for subsequent systematic reviews or trials.
儿童颅咽管瘤的手术治疗可能会引发与水和钠相关的紊乱，如中枢性尿崩症（CDI）和脑性盐耗综合征（CSWS）。儿童同时出现这两种情况在文献中鲜有报道，且与高死亡率相关。CSWS的治疗以液体疗法为基础。氟氢可的松对液体管理无反应的CSWS患儿有用。本文的目的是描述一名6岁10个月大的男童病例，该患儿因7个月前进行的颅咽管瘤手术继发垂体功能减退，因复发性颅咽管瘤就诊于急诊科。该患儿在此次复发性肿瘤手术后出现了CDI和CSWS的合并情况。氟氢可的松治疗有效。像本报告中的这类儿科患者可为后续的系统评价或试验奠定基础。
