Zhang Jian, Chen Shijian, Yang Chengmin, Liang Huo, Quan Xuemei, Liu Yayuan, Liang Zhijian
Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China.
Front Aging Neurosci. 2024 Sep 25;16:1408685. doi: 10.3389/fnagi.2024.1408685. eCollection 2024.
Voxel-mirrored homotopic connectivity (VMHC) is utilized to assess the functional connectivity of neural networks by quantifying the similarity between corresponding regions in the bilateral hemispheres of the brain. The exploration of VMHC abnormalities in basal ganglia ischemic stroke (BGIS) patients across different cerebral hemispheres has been limited. This study seeks to establish a foundation for understanding the functional connectivity status of both brain hemispheres in BGIS patients through the utilization of VMHC analysis utilizing resting-state functional magnetic resonance imaging (rs-fMRI).
This study examined a total of 38 patients with left basal ganglia ischemic stroke (LBGIS), 44 patients with right basal ganglia ischemic stroke (RBGIS), and 41 individuals in a healthy control (HC) group. Rs-fMRI studies were performed on these patients, and the pre-processed rs-fMRI data were analyzed using VMHC method. Subsequently, the VMHC values were compared between three groups using a one-way ANOVA and analysis. Correlation analysis with clinical scales was also conducted.
The results indicated that compared to the HC group, significant differences were detected in postcentral gyrus, extending to precentral gyrus in both BGIS groups. analysis showed that in the pairwise ROI-based comparison, individuals with LBGIS and RBGIS exhibited reduced VMHC values compared to HC groups. There was no significant difference between the LBGIS and RBGIS groups. In the LBGIS group, the VMHC value showed a negative correlation with NIHSS and a positive correlation with BI.
The analysis of VMHC in rs-fMRI revealed a pattern of brain functional remodeling in patients with unilateral BGIS, marked by reduced synchronization and coordination between hemispheres. This may contribute to the understanding of the neurological mechanisms underlying motor dysfunction in these patients.
体素镜像同伦连接性（VMHC）用于通过量化大脑双侧半球相应区域之间的相似性来评估神经网络的功能连接性。对基底节区缺血性卒中（BGIS）患者不同大脑半球VMHC异常的探索一直有限。本研究旨在通过利用静息态功能磁共振成像（rs-fMRI）的VMHC分析，为了解BGIS患者双侧大脑半球的功能连接状态奠定基础。
本研究共检查了38例左侧基底节区缺血性卒中（LBGIS）患者、44例右侧基底节区缺血性卒中（RBGIS）患者和41名健康对照（HC）组个体。对这些患者进行了rs-fMRI研究，并使用VMHC方法分析预处理后的rs-fMRI数据。随后，使用单因素方差分析和分析比较三组之间的VMHC值。还进行了与临床量表的相关性分析。
结果表明，与HC组相比，两个BGIS组的中央后回均检测到显著差异，并延伸至中央前回。分析表明，在基于感兴趣区域（ROI）的两两比较中，LBGIS和RBGIS个体的VMHC值低于HC组。LBGIS组和RBGIS组之间无显著差异。在LBGIS组中，VMHC值与美国国立卫生研究院卒中量表（NIHSS）呈负相关，与巴氏指数（BI）呈正相关。
rs-fMRI中VMHC的分析揭示了单侧BGIS患者的脑功能重塑模式，其特征是半球间同步和协调减少。这可能有助于理解这些患者运动功能障碍的神经机制。
