Malunjkar Nikhil, Tiwari Pradeep, Momale Neha, Pujari Vijayalaxmi, Patil Smita, Barua Arundhati, Lohakare Tejaswee
General Medicine, Padmashree Dr. D.Y. Patil School of Medicine, Nerul, IND.
Child Health Nursing, Smt. Radhikabai Meghe Memorial College of Nursing, Wardha, IND.
Cureus. 2024 Sep 9;16(9):e68985. doi: 10.7759/cureus.68985. eCollection 2024 Sep.
Subacute sclerosing panencephalitis (SSPE) is a late effect of measles in children. Its features include seizures, a gradual loss of physical and cognitive function, and finally death. Despite the absence of a definitive cure for this disorder, a regimen combining intrathecal interferon-α (IFN-α) and daily oral isoprinosine has demonstrated effectiveness. We present the case of a 24-year-old male with spastic seizure epilepsy. He exhibited progressive weakness, frequent postural instability, and recurrent generalized tonic-clonic seizures. Increased measles antibody concentrations in the cerebrospinal fluid (CSF), prominent amplitude spikes on the electroencephalogram (EEG), and heightened fluid-attenuated inversion recovery (FLAIR) signals on brain magnetic resonance imaging (MRI) suggested a diagnosis of SSPE.
亚急性硬化性全脑炎（SSPE）是儿童麻疹的晚期并发症。其特征包括癫痫发作、身体和认知功能逐渐丧失，最终导致死亡。尽管目前尚无针对该疾病的确切治愈方法，但鞘内注射干扰素-α（IFN-α）和每日口服异丙肌苷的联合治疗方案已显示出有效性。我们报告一例24岁患有痉挛性癫痫发作的男性病例。他表现出进行性肌无力、频繁的姿势不稳以及反复发作的全身性强直阵挛性癫痫发作。脑脊液（CSF）中麻疹抗体浓度升高、脑电图（EEG）上明显的振幅尖峰以及脑磁共振成像（MRI）上液体衰减反转恢复（FLAIR）信号增强提示诊断为SSPE。
