门体分流在血吸虫性肝纤维化患者特异性体液免疫反应中的作用。

The role of porto-systemic shunts in the specific humoral immune response in patients with schistosomal hepatic fibrosis.

作者信息

Helmy-Khalil S, Khalil S A, el Sawy M, Youssef M, el Kader M A, el Hallous D, el Balassy F, Souka M, el Girby A, Fahmy M H

出版信息

Ann Biol Clin (Paris). 1985;43(6):856-60.

PMID:3938625

Abstract

The present study was devoted to elucidate the role of collaterals (porto-systemic shunts) in the specific humoral immune response to schistosomal soluble egg antigen (SEA) in patients with schistosomal hepatic fibrosis (SHF). Twenty five patients with SHF with collaterals, ten patients with SHF without collaterals and twenty healthy control subjects constituted the material of this study. In vivo and in vitro tests for humoral immunity to SEA included serum immunoglobulins estimation, immediate intradermal test, indirect haemagglutination test and determination of B lymphocytes count in peripheral blood. Significant differences have been observed between cases without collaterals and those with collaterals; and in the latter group before and after decongestion. These results tend to consolidate the view of the role of collaterals in schistosomal antigenemia and subsequent humoral immune response.

摘要

本研究旨在阐明侧支循环（门体分流）在血吸虫性肝纤维化（SHF）患者对血吸虫可溶性虫卵抗原（SEA）的特异性体液免疫反应中的作用。25例有侧支循环的SHF患者、10例无侧支循环的SHF患者和20名健康对照者构成了本研究的材料。对SEA的体液免疫的体内和体外试验包括血清免疫球蛋白测定、直接皮内试验、间接血凝试验以及外周血B淋巴细胞计数的测定。在无侧支循环的病例与有侧支循环的病例之间；以及在后一组病例中，在充血消除前后，均观察到了显著差异。这些结果倾向于巩固侧支循环在血吸虫抗原血症及随后的体液免疫反应中的作用这一观点。