Chinoy D A, Breaux P C, Ibrahim F
Clin Ther. 1985;8(1):30-4.
The adhesive properties of two transdermal nitroglycerin controlled-release systems, Transderm-Nitro (TDN) and Nitro-Dur (ND), were compared in 65 patients receiving treatment for angina pectoris. Patients applied transdermal patches of both systems daily (randomized as to side of body applied) for four weeks and maintained daily diaries recording number of angina attacks, additional nitroglycerin use, patch adhesion, and skin problems. A total of 1,702 TDN and 1,692 ND patches were applied, of which six (0.4%) TDN and 83 (4.9%) ND fell off. An additional 4.8% of TDN patches and 16.2% of ND patches adhered only partially. Problems at site of application, such as itching, rash, or redness, were reported with both patches but were far more frequent with ND than with TDN. Patients preferred TDN (86.2%) over ND (9.2%).
在65例接受心绞痛治疗的患者中，比较了两种经皮硝酸甘油控释系统——硝酸甘油透皮贴剂（TDN）和硝酸酯类长效贴剂（ND）的黏附特性。患者每天使用这两种系统的透皮贴剂（随机选择贴于身体的一侧），持续四周，并每天记录心绞痛发作次数、额外使用硝酸甘油的情况、贴剂的黏附情况以及皮肤问题。共使用了1702片TDN贴剂和1692片ND贴剂，其中6片（0.4%）TDN贴剂和83片（4.9%）ND贴剂脱落。另外，4.8%的TDN贴剂和16.2%的ND贴剂仅部分黏附。两种贴剂均报告了应用部位的问题，如瘙痒、皮疹或发红，但ND贴剂出现这些问题的频率远高于TDN贴剂。患者更喜欢TDN（86.2%）而非ND（9.2%）。
