The Affiliated Hospital of Qingdao University, Qingdao, China.
Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Public Health. 2024 Sep 25;12:1393743. doi: 10.3389/fpubh.2024.1393743. eCollection 2024.
Medical health workers play an essential role in the healthcare system and face unique workplace stressors. However, the impact of psychological stress on their physical health has received less attention compared to the general population.
We retrospectively analyzed the Self-rating Depression Scale (SDS) questionnaires and blood testing results from 1963 medical health workers. Multivariate linear regression analysis using a backward stepwise selection strategy to identify physical examination indicators that were significantly affected by depression.
Depression severity, as measured by SDS index score, was positively correlated with the levels of hemoglobin (coefficient 0.0027, = 0.0412), platelet count (coefficient 0.0005, = 0.0198), and uric acid (coefficient 0.0004, = 0.0492), while negatively correlated with red blood cell count (coefficient-0.0895, = 0.0406). Similar results were observed in the subgroup analysis stratified by age and sex.
Our study found a significant association between higher levels of depression and specific physiological indicators in healthcare professionals, including elevated hemoglobin, platelet counts, and uric acid levels, as well as decreased red blood cell counts. These changes in blood parameters may reflect underlying physiological stress and inflammation, potentially increasing overall health risks for healthcare workers. Addressing these physiological changes may be crucial for mitigating the health risks associated with depression. To validate our findings and develop targeted interventions, larger multi-center studies are needed to further explore the relationship between depression severity and blood parameters in healthcare professionals.
医疗保健工作者在医疗体系中发挥着至关重要的作用，他们面临着独特的工作场所压力源。然而，与一般人群相比，心理压力对他们身体健康的影响尚未得到足够的关注。
我们回顾性分析了 1963 名医疗保健工作者的自评抑郁量表（SDS）问卷和血液检测结果。采用逐步后退选择策略的多变量线性回归分析，以确定受抑郁显著影响的体检指标。
SDS 指数评分衡量的抑郁严重程度与血红蛋白（系数 0.0027，=0.0412）、血小板计数（系数 0.0005，=0.0198）和尿酸（系数 0.0004，=0.0492）水平呈正相关，而与红细胞计数（系数-0.0895，=0.0406）呈负相关。在按年龄和性别分层的亚组分析中也观察到了类似的结果。
我们的研究发现，较高水平的抑郁与医疗保健专业人员特定的生理指标之间存在显著关联，包括血红蛋白、血小板计数和尿酸水平升高，以及红细胞计数降低。这些血液参数的变化可能反映了潜在的生理应激和炎症，可能会增加医疗保健工作者的整体健康风险。针对这些生理变化进行干预可能对于减轻与抑郁相关的健康风险至关重要。为了验证我们的发现并制定有针对性的干预措施，需要进行更大规模的多中心研究，以进一步探讨医疗保健专业人员中抑郁严重程度与血液参数之间的关系。
