Veterinary School, Orumiyeh University, Orumiyeh, Iran.
Clinical Biochemistry, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Brain Behav. 2020 Apr;10(4):e01569. doi: 10.1002/brb3.1569. Epub 2020 Feb 25.
Cardiovascular disorders are common in patients with panic disorder (PD), usually mediated by platelets. The present study was conducted to evaluate oxidative stress conditions and complete analysis of blood cells in patients with PD.
Sixty healthy individuals and 60 patients were included in the study. Whole blood and serum samples were obtained from patients and controls.
MATERIALS & METHOD: Hematological studies, including blood cells count, hemoglobin, and hematocrit, were carried out on whole blood samples. In addition, oxidative stress indices including total antioxidant capacity, free oxygen species, and malondialdehyde concentration were measured in serum samples.
Results showed that patients with PD had a significant increase in mean platelet volume index (MPV), platelet distribution width (PDW), red blood cell distribution width (RDW), and mean corpuscular hemoglobin concentration (MCHC) compared with healthy subjects (p < .05). Also, oxidative stress indices were significantly elevated in patients with PD compared with control group (p < .05).
Elevated MPV is a hematologic indicator for patients with PD. This disorder may be caused by impaired serotonin metabolism, resulting in increased oxidative stress, as well as in platelet serotonin transporters. Regarding elevated oxidative stress, the risk of cardiovascular complications is high in patients with PD.
心血管疾病在惊恐障碍（PD）患者中很常见，通常由血小板介导。本研究旨在评估 PD 患者的氧化应激状况和全血细胞分析。
本研究纳入了 60 名健康个体和 60 名患者。从患者和对照者中采集全血和血清样本。
对全血样本进行血液学研究，包括血细胞计数、血红蛋白和血细胞比容。此外，还测量了血清样本中的氧化应激指标，包括总抗氧化能力、游离氧物种和丙二醛浓度。
结果显示，与健康受试者相比，PD 患者的平均血小板体积指数（MPV）、血小板分布宽度（PDW）、红细胞分布宽度（RDW）和平均红细胞血红蛋白浓度（MCHC）显著升高（p<0.05）。此外，与对照组相比，PD 患者的氧化应激指标显著升高（p<0.05）。
MPV 升高是 PD 患者的血液学指标。这种疾病可能是由于 5-羟色胺代谢受损，导致氧化应激增加，以及血小板 5-羟色胺转运体增加所致。关于氧化应激升高，PD 患者发生心血管并发症的风险很高。
