Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA.
Cell Reprogram. 2024 Oct;26(5):132-134. doi: 10.1089/cell.2024.0077. Epub 2024 Oct 10.
Tumors evade immune detection by downregulating antigen presentation and hindering immune responses. Type 1 conventional dendritic cells (cDC1s) are vital in stimulating cytotoxic T cells against tumors. Ascic et al. are now demonstrating the ability of PU.1, IRF8, and BATF3 (PIB) transcription factors to directly reprogram a plethora of tumors bypassing the suppressive effects of the tumor microenvironment, and leading to overall tumor regression while eliciting a systemic immune response that can protect from secondary tumor induction.
肿瘤通过下调抗原呈递和阻碍免疫反应来逃避免疫检测。1 型常规树突状细胞（cDC1）在刺激针对肿瘤的细胞毒性 T 细胞方面至关重要。Ascic 等人现在证明了 PU.1、IRF8 和 BATF3（PIB）转录因子的能力，可以直接重编程大量肿瘤，绕过肿瘤微环境的抑制作用，导致肿瘤整体消退，并引发可以预防继发性肿瘤诱导的全身性免疫反应。
