通过铁催化肟酯与4-羟基香豆素的接力环化反应构建呋喃香豆素
The Construction of Furocoumarins through Iron-Catalyzed Relay Annulation of Oxime Esters with 4-Hydroxycoumarins.
作者信息
Jiang Kun, Liu Qing-Peng, Zhou Yu-Qiang, Yu Ning, Li Lei, Wei Ye
机构信息
Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Chongqing Institute for Food and Drug Control, NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances, Chongqing, 401121, China.
出版信息
Org Lett. 2024 Oct 18;26(41):8741-8746. doi: 10.1021/acs.orglett.4c03063. Epub 2024 Oct 10.
An iron-catalyzed relay annulation protocol was disclosed, which utilizes oxime esters and 4-hydroxycoumarins as the readily available starting materials and showcases broad substrate scope and good functional group tolerance. This method allows the simultaneous generation of two C-C and one C-O bonds and two rings in one step, affording structurally new furocoumarins in moderate to good yields.
公开了一种铁催化的接力环化反应方案，该方案利用肟酯和4-羟基香豆素作为易于获得的起始原料，展示了广泛的底物范围和良好的官能团耐受性。该方法能够一步同时生成两个C-C键和一个C-O键以及两个环，以中等至良好的产率得到结构新颖的呋喃香豆素。
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