Zhang Xiao-Feng, Min Rui-Xue, Wang Zhen, Qi Yue, Li Ruo-Nan, Fan Jian-Ming
Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Phytother Res. 2024 Dec;38(12):5873-5900. doi: 10.1002/ptr.8339. Epub 2024 Oct 10.
Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta-analysis synthesized the effect of ginseng consumption on biomarkers of CVH in adults. A systematic search was performed in the databases of PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through July 24, 2023 to screen out English-language randomized controlled trials (RCTs) evaluating the effects of ginseng consumption on body composition, blood pressure, vascular stiffness, lipid metabolism, glucose metabolism, insulin resistance, inflammatory cytokines, and adipocytokines in adults. The weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate the overall effect size, and STATA 12.0 was used for comprehensive analysis. Forty-five studies were included in the meta-analysis. Ginseng consumption significantly reduced systolic blood pressure (SBP) (WMD = -2.57 mmHg, 95% CI = -4.99 to -0.14, p = 0.038), total cholesterol (TC) (WMD = -4.40 mg/dL, 95% CI = -8.67 to -0.132, p = 0.043), low density lipoprotein cholesterol (LDL-C) (WMD = -2.81 mg/dL, 95% CI = -4.89 to -0.72, p = 0.008), C-reactive protein (CRP) (WMD = -0.41 mg/L, 95% CI = -0.73 to -0.10, p = 0.010), and interleukin-6 (IL-6) (WMD = -2.82 pg./mL, 95% CI = -4.31 to -1.32, p < 0.001). Subgroup analyses suggested that supplementation with ginseng for less than 12 weeks significantly reduced SBP, but 12 weeks or more improved TC and CRP. Ginseng consumption on SBP, TC, and CRP seemed to be more effective on unhealthy participants. The meta-analysis showed that ginseng consumption might have the potential to improve SBP, TC, LDL-C, CRP, and IL-6. These findings suggest that ginseng is a potential candidate for the maintenance of CVH. However, our results had high heterogeneity. Future high-quality studies are needed to firmly establish the clinical efficacy of ginseng consumption.
人参具有多种药理活性，在改善心血管健康（CVH）方面受到越来越多的关注。因此，本荟萃分析综合了食用人参对成年人CVH生物标志物的影响。通过在PubMed、Scopus、Web of Science、Embase和Cochrane图书馆数据库中进行系统检索，截至2023年7月24日，筛选出评估食用人参对成年人身体成分、血压、血管硬度、脂质代谢、葡萄糖代谢、胰岛素抵抗、炎性细胞因子和脂肪细胞因子影响的英文随机对照试验（RCT）。采用加权平均差（WMD）和95%置信区间（CI）评估总体效应大小，并使用STATA 12.0进行综合分析。荟萃分析纳入了45项研究。食用人参显著降低收缩压（SBP）（WMD = -2.57 mmHg，95% CI = -4.99至-0.14，p = 0.038）、总胆固醇（TC）（WMD = -4.40 mg/dL，95% CI = -8.67至-0.132，p =
