ProMedica Jobst Wound Care, Toledo, OH, US.
Professor of Surgery, Plastic Surgery, University of Toledo College of Medicine, Toledo, OH, US.
J Wound Care. 2024 Oct 2;33(10):772-777. doi: 10.12968/jowc.2024.0085. Epub 2024 Sep 5.
Innovation in wound healing, particularly regarding diabetic foot ulcers (DFUs), is needed to reverse the number of diabetes-related amputations. This study evaluated a novel approach and performance of a multimodal wound matrix in converting stalled DFUs into a healing trajectory.
Patients with either type 1 or 2 diabetes and with foot ulcers (Wagner grade 1 and 2), were screened to determine eligibility for treatment. Ulcers improving >30% in area during a two-week screening phase were not eligible for the study treatment phase. The study was an open-label trial conducted in three phases: screening, treatment and healing confirmation. Patients enrolled in the study received a treatment protocol that included application of a wound matrix to the ulcer and offloading.
A total of 19 patients (15 males, four females) with a median age of 60 years, and a median ulcer duration of 36 weeks took part in the study. Patients showed an average four-week percentage area reduction (PAR) of 62%, a 12-week PAR of 94%, and a 12-week healing rate of 57% (8/14).
Results of this study support the viability and potential of a novel approach to treating DFUs that includes use of a multimodal wound matrix.
需要在伤口愈合方面进行创新，特别是针对糖尿病足溃疡（DFU），以扭转与糖尿病相关的截肢数量。本研究评估了一种新型多模式伤口基质的方法和性能，以将停滞的 DFU 转化为愈合轨迹。
筛选患有 1 型或 2 型糖尿病且足部溃疡（Wagner 分级 1 和 2）的患者，以确定其是否有资格接受治疗。在两周的筛选阶段中，溃疡面积改善>30%的患者不符合研究治疗阶段的条件。本研究为开放性试验，分为三个阶段进行：筛选、治疗和愈合确认。入组研究的患者接受了包括在溃疡上应用伤口基质和减压的治疗方案。
共有 19 名患者（15 名男性，4 名女性）参加了研究，中位年龄为 60 岁，中位溃疡持续时间为 36 周。患者在四周时的平均面积减少百分比（PAR）为 62%，十二周时的 PAR 为 94%，十二周时的愈合率为 57%（8/14）。
本研究结果支持一种治疗 DFU 的新方法的可行性和潜力，该方法包括使用多模式伤口基质。
